General Dosage
300mg daily of standardized ASU extract (1:2 avocado:soybean ratio)
Maximum dose: 600mg daily has been studied (Maheu et al., 1998) but showed no additional benefit over 300mg
Avocado Soy Unsaponifiables (ASU) Dosage Guide
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Dosage Recommendations
General recommendation: 300mg daily of standardized ASU extract (1:2 avocado:soybean ratio)
Timing: Take with a meal to enhance absorption of fat-soluble compounds; consistent daily use for at least 2-3 months • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Knee osteoarthritis | 300mg daily for 3+ months | Strong |
| Hip osteoarthritis | 300mg daily for 3+ months | Strong |
| OA with high NSAID use | 300mg daily to reduce analgesic dependence | Moderate |
Upper limit: 600mg daily has been studied (Maheu et al., 1998) but showed no additional benefit over 300mg
Timing & Absorption
Take with a meal to enhance absorption of fat-soluble compounds; consistent daily use for at least 2-3 months
Best taken with food for optimal absorption.
References
- Maheu E, Mazieres B, Valat JP, et al. (1998). Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial. Arthritis & Rheumatism. DOI PubMed
- Maheu E, Cadet C, Marty M, et al. (2014). Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Annals of the Rheumatic Diseases. DOI PubMed
- Appelboom T, Schuermans J, Verbruggen G, et al. (2001). Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. Scandinavian Journal of Rheumatology. DOI PubMed
- Christensen R, Bartels EM, Astrup A, Bliddal H (2008). Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis and Cartilage. DOI PubMed