Safety Profile
Overall safety rating: Generally Safe
Avocado Soy Unsaponifiables (ASU) Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Mild GI discomfort (rare)
- Allergic reactions in individuals with soy allergy
- Very well tolerated — adverse event rates comparable to placebo in large trials
Drug & Supplement Interactions
- No significant drug interactions reported
- Safe to combine with glucosamine, chondroitin, and other joint supplements
- May allow reduced NSAID dosage — discuss with healthcare provider
Maximum Dose
Do not exceed: 600mg daily has been studied (Maheu et al., 1998) but showed no additional benefit over 300mg
References
- Maheu E, Mazieres B, Valat JP, et al. (1998). Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial. Arthritis & Rheumatism. DOI PubMed
- Maheu E, Cadet C, Marty M, et al. (2014). Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Annals of the Rheumatic Diseases. DOI PubMed
- Appelboom T, Schuermans J, Verbruggen G, et al. (2001). Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. Scandinavian Journal of Rheumatology. DOI PubMed
- Christensen R, Bartels EM, Astrup A, Bliddal H (2008). Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis and Cartilage. DOI PubMed