Safety Profile
Overall safety rating: Generally Safe
Adrenal Support Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Overstimulation or jitteriness (especially with stimulating adaptogens like eleuthero)
- GI upset from multi-ingredient formulas
- Insomnia if taken too late in the day
- Headache (less common)
Drug & Supplement Interactions
- Adaptogens may interact with thyroid medications (ashwagandha particularly)
- May enhance or interfere with anti-anxiety and antidepressant medications
- Adrenal glandulars may contain hormones that interact with HRT or corticosteroid medications
- Rhodiola may affect CYP3A4 substrates — caution with many prescription drugs
Maximum Dose
Do not exceed: Varies by ingredient — do not exceed individual ingredient maximums
References
- Lopresti AL, Smith SJ, Malvi H, Kodgule R (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. Medicine. DOI PubMed
- Olsson EM, von Schéele B, Panossian AG (2009). A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Medica. DOI PubMed
- Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D (2004). Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. DOI PubMed