General Dosage
250-500mg daily for cognitive enhancement
Maximum dose: 2000mg/day (clinical stroke doses; supplement doses typically cap at 500mg)
CDP-Choline (Citicoline) Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 250-500mg daily for cognitive enhancement
Timing: Morning or early afternoon; can be split into two doses
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Focus and attention | 250-500mg daily | Strong |
| Memory support | 500-1000mg daily | Moderate |
| Stroke recovery | 500-2000mg daily (under medical supervision) | Strong |
| Neuroprotection | 500mg daily long-term | Moderate |
Upper limit: 2000mg/day (clinical stroke doses; supplement doses typically cap at 500mg)
Timing & Absorption
Morning or early afternoon; can be split into two doses
Can be taken with or without food.
References
- McGlade E, Locatelli A, Hardy J, et al. (2012). Improved attentional performance following citicoline administration in healthy adult women. Food and Nutrition Sciences. DOI
- Gareri P, Castagna A, Cotroneo AM, et al. (2015). The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clinical Interventions in Aging. DOI PubMed
- Dávalos A, Alvarez-Sabín J, Castillo J, et al. (2012). Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). The Lancet. DOI PubMed