Skip to main content
Supplement ScienceSupplementScience

CDP-Choline (Citicoline) Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

250-500mg daily for cognitive enhancement

Maximum dose: 2000mg/day (clinical stroke doses; supplement doses typically cap at 500mg)

Dosage Recommendations

General recommendation: 250-500mg daily for cognitive enhancement

Timing: Morning or early afternoon; can be split into two doses

Dosage by Condition

Focus and attention
250-500mg dailyStrong
Memory support
500-1000mg dailyModerate
Stroke recovery
500-2000mg daily (under medical supervision)Strong
Neuroprotection
500mg daily long-termModerate

Upper limit: 2000mg/day (clinical stroke doses; supplement doses typically cap at 500mg)

Timing & Absorption

Morning or early afternoon; can be split into two doses

Can be taken with or without food.

Full CDP-Choline (Citicoline) Guide

References

  1. McGlade E, Locatelli A, Hardy J, et al. (2012). Improved attentional performance following citicoline administration in healthy adult women. Food and Nutrition Sciences. DOI
  2. Gareri P, Castagna A, Cotroneo AM, et al. (2015). The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clinical Interventions in Aging. DOI PubMed
  3. RCTDávalos A, Alvarez-Sabín J, Castillo J, et al. (2012). Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). The Lancet. DOI PubMed