D-Aspartic Acid — Frequently Asked Questions
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Frequently Asked Questions
Does D-Aspartic Acid actually increase testosterone?
Does D-Aspartic Acid actually increase testosterone?
Results are mixed. The original 2009 study showed a 42% increase in sedentary men after 12 days. However, studies in resistance-trained men found no significant testosterone elevation. DAA may benefit men with suboptimal testosterone (older, sedentary, or subfertile) but appears ineffective for young, trained men who already have healthy testosterone levels.
Should I cycle D-Aspartic Acid?
Should I cycle D-Aspartic Acid?
Most practitioners recommend cycling DAA (2-3 weeks on, 1-2 weeks off) because the testosterone-elevating effect appears transient — levels returned to baseline within days of cessation in the original study. Cycling may prevent adaptation. There is no strong evidence that continuous long-term use is either more effective or dangerous.
Is D-Aspartic Acid the same as regular aspartic acid?
Is D-Aspartic Acid the same as regular aspartic acid?
No. D-Aspartic Acid is the D-enantiomer (mirror image) of L-aspartic acid. L-aspartic acid is used in protein synthesis and has no testosterone-boosting effects. D-aspartic acid specifically acts on the neuroendocrine system to stimulate LH and testosterone. Supplements must contain the D-form to have potential hormonal effects.
References
- Topo E, Soricelli A, D'Aniello A, et al. (2009). The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reproductive Biology and Endocrinology. DOI PubMed
- Willoughby DS, Leutholtz B. (2013). D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones. Nutrition Research. DOI PubMed
- Melville GW, Siegler JC, Marshall PW. (2015). Three and six grams supplementation of d-aspartic acid in resistance trained men. Journal of the International Society of Sports Nutrition. DOI PubMed