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D-Aspartic Acid Research & Evidence

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Evidence Level

Preliminary

D-Aspartic Acid generated excitement with the 2009 Topo et al. study showing 42% testosterone increases. However, subsequent research in resistance-trained men (Willoughby & Leutholtz 2013; Melville et al. 2015) showed no significant testosterone elevation, suggesting the initial findings may not apply to young, active men with already-optimal testosterone. DAA may be more useful for subfertile men or those with suboptimal testosterone due to age or lifestyle factors.

Evidence by Condition

ConditionStudied DoseEvidence
Testosterone support (untrained men)2-3 g daily for 12-28 daysPreliminary
Male fertility2.66 g daily for 90 daysPreliminary
Full D-Aspartic Acid Guide

References

  1. (). The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reproductive Biology and Endocrinology. DOI
  2. (). D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones. Nutrition Research. DOI
  3. (). Three and six grams supplementation of d-aspartic acid in resistance trained men. Journal of the International Society of Sports Nutrition. DOI