Skip to main content
Supplement ScienceSupplementScience

D-Aspartic Acid Side Effects & Safety

Evidence:Preliminary
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Headache and irritability reported in some users
  • Acne or oily skin (related to androgen fluctuations)
  • GI discomfort at higher doses
  • Possible mood changes during cycling

Drug & Supplement Interactions

  • Testosterone replacement therapy — additive hormonal effects; avoid combining
  • Aromatase inhibitors — DAA-induced testosterone may convert to estrogen without AI
  • DHEA and other hormonal supplements — additive effects on hormone levels

Maximum Dose

Do not exceed: 6 g/day has been studied but showed a paradoxical decrease in testosterone in one study

Full D-Aspartic Acid Guide

References

  1. RCTWilloughby DS, Leutholtz B. (2013). D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones. Nutrition Research. DOI PubMed
  2. RCTMelville GW, Siegler JC, Marshall PW. (2015). Three and six grams supplementation of d-aspartic acid in resistance trained men. Journal of the International Society of Sports Nutrition. DOI PubMed
  3. RCTGamalEl Din SF, A M E, Elkhiat Y, Hussein T, et al. (2025). Evaluation of in vivo supplementation of 2660 mg D-aspartic acid and 200 mg ubiquinol and 10 mg zinc on different semen parameters in idiopathic male infertility: a randomized double blind placebo controlled study.. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. DOI PubMed
  4. RCTPłoszczyca K, Czuba M, Zakrzeska A, Gajda R (2023). The Effects of Six-Gram D-Aspartic Acid Supplementation on the Testosterone, Cortisol, and Hematological Responses of Male Boxers Subjected to 11 Days of Nocturnal Exposure to Normobaric Hypoxia.. Nutrients. DOI PubMed
  5. Crewther B, Witek K, Draga P, Zmijewski P, et al. (2019). Short-Term d-Aspartic Acid Supplementation Does Not Affect Serum Biomarkers Associated With the Hypothalamic-Pituitary-Gonadal Axis in Male Climbers.. International journal of sport nutrition and exercise metabolism. DOI PubMed
  6. Melville GW, Siegler JC, Marshall PWM (2017). The effects of d-aspartic acid supplementation in resistance-trained men over a three month training period: A randomised controlled trial.. PloS one. DOI PubMed
  7. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, et al. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. PubMed
Show 2 more references
  1. Tricco AC, Vandervaart S, Soobiah C, Lillie E, et al. (2012). Efficacy of cognitive enhancers for Alzheimer's disease: protocol for a systematic review and network meta-analysis.. Systematic reviews. DOI PubMed
  2. RCTTopo E, Soricelli A, D'Aniello A, et al. (2009). The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reproductive Biology and Endocrinology. DOI PubMed