Evidence Level
Strong
EAAs have strong evidence as a complete muscle protein synthesis stimulus. Wolfe's 2017 review established that all 9 EAAs are required for maximal MPS — BCAAs alone cannot sustain the response because the other 6 EAAs become rate-limiting. As few as 6 g EAAs can stimulate MPS comparably to much larger doses of whole protein, making them calorie-efficient. They are particularly valuable for older adults, clinical populations, and athletes training fasted.