Evidence Level
Gotu kola has demonstrated potential benefits in cognitive function and wound healing. A randomized, placebo-controlled study by Wattanathorn et al. (2008) found that high-dose Centella asiatica improved working memory and mood in healthy elderly volunteers over a 2-month period. Additionally, Brinkhaus et al. (2000) reviewed multiple trials supporting the use of TECA extract for wound healing, highlighting its clinical efficacy.
Recent research has further explored Gotu kola's cognitive effects. Wightman et al. (2023) conducted a randomized, placebo-controlled trial involving 128 older adults and found that a multi-ingredient herbal supplement containing Gotu kola enhanced the speed of cognitive task performance. However, Phoemsapthawee et al. (2022) reported in a study of 60 older adults with mild cognitive impairment (MCI) that while multicomponent exercise alone or with Gotu kola improved cognitive function and reduced inflammation/oxidative stress, Gotu kola did not add significant cognitive benefits beyond exercise.
Safety considerations are important. Rare cases of hepatotoxicity have been reported, leading to recommendations for cyclic use rather than continuous long-term supplementation. This aligns with findings from Kaziulin et al. (2006), who observed improvements in patients with hepatic encephalopathy using a supplement containing bioactive substances, though Gotu kola was not the sole component.
Overall, Gotu kola shows promise in specific contexts, but its use should be guided by evidence and individual health profiles.