General Dosage
3-6 g daily, divided into 2-3 doses
Maximum dose: Up to 20 g/day used in clinical studies; GI side effects common above 10 g/day
L-Arginine Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 3-6 g daily, divided into 2-3 doses
Timing: Divided doses 2-3 times daily on an empty stomach; pre-workout for exercise
Dosage by Condition
Blood pressure support
4-6 g daily in divided dosesModerate
Erectile dysfunction
3-5 g dailyModerate
Exercise performance
3-6 g 30-60 min pre-workoutModerate
Wound healing
4.5-9 g dailyModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Blood pressure support | 4-6 g daily in divided doses | Moderate |
| Erectile dysfunction | 3-5 g daily | Moderate |
| Exercise performance | 3-6 g 30-60 min pre-workout | Moderate |
| Wound healing | 4.5-9 g daily | Moderate |
Upper limit: Up to 20 g/day used in clinical studies; GI side effects common above 10 g/day
Timing & Absorption
Divided doses 2-3 times daily on an empty stomach; pre-workout for exercise
Can be taken with or without food.
References
- Dong JY, Qin LQ, Zhang Z, et al. (2011). Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. American Heart Journal. DOI PubMed
- Rhim HC, Kim MS, Park YJ, et al. (2019). The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. Journal of Sexual Medicine. DOI PubMed
- Schwedhelm E, Maas R, Freese R, et al. (2008). Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine. British Journal of Clinical Pharmacology. DOI PubMed