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L-Citrulline — Frequently Asked Questions

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Frequently Asked Questions

Is citrulline better than arginine?

Yes, for raising blood arginine and nitric oxide levels. L-arginine undergoes extensive first-pass metabolism in the liver (arginase breaks it down), so much of an oral dose never reaches the bloodstream. L-citrulline bypasses the liver, is converted to arginine in the kidneys, and results in higher and more sustained plasma arginine levels.

What is the difference between L-citrulline and citrulline malate?

Citrulline malate combines L-citrulline with malic acid (typically 2:1 ratio). The malate may provide additional benefits for ATP production via the Krebs cycle, though this is debated. To get 6 g of citrulline from a 2:1 citrulline malate, you need about 8 g of the combined product. Pure L-citrulline is fine if you just want the NO-boosting effects.

When should I take citrulline for best results?

Take 30-60 minutes before exercise for peak plasma levels during your workout. For ongoing cardiovascular support, daily dosing is effective regardless of timing. Citrulline can be taken on an empty stomach and is often mixed into pre-workout drinks.

Full L-Citrulline Guide

References

  1. (). Acute effects of citrulline supplementation on high-intensity strength and power performance: a systematic review and meta-analysis. Sports Medicine. DOI
  2. (). Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. British Journal of Clinical Pharmacology. DOI