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SupplementScience

L-Tyrosine Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Very well tolerated
  • Mild headache in rare cases
  • Possible GI discomfort at high doses
  • May cause anxiety or overstimulation in susceptible individuals

Drug & Supplement Interactions

  • MAOIs — contraindicated; excessive catecholamine accumulation risk
  • Levodopa — tyrosine competes with levodopa for brain transport
  • Thyroid medications — tyrosine is a thyroid hormone precursor; monitor thyroid levels

Maximum Dose

Do not exceed: 12 g/day (150 mg/kg) has been used in military studies; 2 g/day is typical for supplements

Full L-Tyrosine Guide

References

  1. (). Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior. DOI
  2. (). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands — a review. Journal of Psychiatric Research. DOI