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Meso-Zeaxanthin — Frequently Asked Questions

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Frequently Asked Questions

Why do I need meso-zeaxanthin if I already take lutein and zeaxanthin?

The macula has three layers of carotenoid pigment: lutein (outer), zeaxanthin (middle), and meso-zeaxanthin (inner center). The CREST trial showed that supplementing all three increased macular pigment density more effectively than just two. Meso-zeaxanthin protects the very center of your sharpest vision.

Why is meso-zeaxanthin not in the AREDS2 formula?

AREDS2 was designed before meso-zeaxanthin research was mature. At the time, only lutein and zeaxanthin were well-characterized macular pigments. Subsequent research (CREST trials) showed the benefit of including meso-zeaxanthin. Some newer eye supplements now include all three carotenoids.

Can I get meso-zeaxanthin from food?

Meso-zeaxanthin is rare in Western diets. Small amounts are found in certain fish skins (trout, sardines) and shrimp shells. The body can convert some lutein to meso-zeaxanthin in the retina, but this conversion may be insufficient in some individuals, particularly those with AMD.

Full Meso-Zeaxanthin Guide

References

  1. (). Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials — Report 1. Investigative Ophthalmology & Visual Science. DOI
  2. (). Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration. Eye. DOI