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Meso-Zeaxanthin Research & Evidence

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Evidence Level

Moderate

The CREST studies (Central Retinal Enrichment Supplementation Trials) demonstrated that a three-carotenoid formula including meso-zeaxanthin produced greater increases in macular pigment optical density than two-carotenoid formulas. Nolan et al. (2016) showed the triple formula improved contrast sensitivity and visual performance in AMD patients. Meso-zeaxanthin is increasingly recognized as an essential component of comprehensive macular supplementation.

Evidence by Condition

ConditionStudied DoseEvidence
Macular pigment optimization10 mg with lutein 10 mg + zeaxanthin 2 mgModerate
AMD risk reduction10 mg in triple-carotenoid formulaModerate
Visual performance10 mg dailyModerate
Full Meso-Zeaxanthin Guide

References

  1. (). Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials — Report 1. Investigative Ophthalmology & Visual Science. DOI
  2. (). Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration. Eye. DOI