General Dosage
1,000-2,000mg combined EPA+DHA daily (not total fish oil)
Maximum dose: 3,000mg EPA+DHA daily from supplements (FDA generally recognized as safe); up to 4g under medical supervision
Omega-3 Dosage Guide
SC
DJP
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Dosage Recommendations
General recommendation: 1,000-2,000mg combined EPA+DHA daily (not total fish oil)
Timing: With a fat-containing meal for optimal absorption • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Heart health | 1,000-2,000mg EPA+DHA daily; up to 4g EPA for high-risk | Strong |
| Depression/mood | 1,000-2,000mg with EPA-predominant formula (>60% EPA) | Strong |
| Joint pain | 2,000-3,000mg EPA+DHA daily | Moderate |
| Brain health | 1,000mg DHA-predominant daily | Moderate |
Upper limit: 3,000mg EPA+DHA daily from supplements (FDA generally recognized as safe); up to 4g under medical supervision
Timing & Absorption
With a fat-containing meal for optimal absorption
Best taken with food for optimal absorption.
References
- Bhatt DL, Steg PG, Miller M, et al. (2019). Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. New England Journal of Medicine. DOI PubMed
- Liao Y, Xie B, Zhang H, et al. (2019). Efficacy of omega-3 PUFAs in depression: A meta-analysis. Translational Psychiatry. DOI PubMed
- Calder PC (2017). Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society Transactions. DOI PubMed
- Dyall SC (2015). Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Frontiers in Aging Neuroscience. DOI PubMed