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Progesterone Cream (OTC) Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Safe with Caution

Potential Side Effects

  • Drowsiness (due to allopregnanolone metabolite)
  • Breast tenderness
  • Headache
  • Skin irritation at application site
  • Spotting or menstrual cycle changes

Drug & Supplement Interactions

  • May interact with hormonal contraceptives
  • May enhance sedative effects of benzodiazepines and sleep medications
  • Should not be combined with prescription progestins without medical guidance
  • May interact with blood thinners (warfarin)

Maximum Dose

Do not exceed: 40mg daily (OTC); higher doses require prescription

Full Progesterone Cream (OTC) Guide

References

  1. (). Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstetrics & Gynecology. DOI
  2. (). Effect of sequential transdermal progesterone cream on endometrium, bleeding pattern, and plasma progesterone and salivary progesterone levels in postmenopausal women. Climacteric. DOI