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Progesterone Cream (OTC) Side Effects & Safety

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Safe with Caution

Potential Side Effects

  • Drowsiness (due to allopregnanolone metabolite)
  • Breast tenderness
  • Headache
  • Skin irritation at application site
  • Spotting or menstrual cycle changes

Drug & Supplement Interactions

  • May interact with hormonal contraceptives
  • May enhance sedative effects of benzodiazepines and sleep medications
  • Should not be combined with prescription progestins without medical guidance
  • May interact with blood thinners (warfarin)

Maximum Dose

Do not exceed: 40mg daily (OTC); higher doses require prescription

Full Progesterone Cream (OTC) Guide

References

  1. RCTLeonetti HB, Longo S, Anasti JN (1999). Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstetrics & Gynecology. DOI PubMed
  2. RCTWren BG, McFarland K, Edwards L, O'Shea P, Sufi S, Gross B, Eden JA (2000). Effect of sequential transdermal progesterone cream on endometrium, bleeding pattern, and plasma progesterone and salivary progesterone levels in postmenopausal women. Climacteric. DOI PubMed