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Propolis Dosage Guide

Evidence:Moderate
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

300-500mg standardized propolis extract daily

Maximum dose: No established upper limit; studies have used up to 1500mg/day without serious adverse effects

Dosage Recommendations

General recommendation: 300-500mg standardized propolis extract daily

Timing: Between meals; throat spray as needed for sore throat symptoms

Dosage by Condition

Daily immune support
300-500mg extract dailyModerate
Acute cold/sore throat
500mg extract or propolis throat spray 3-4x dailyModerate
Upper respiratory prevention (children)
100-300mg daily during cold seasonModerate

Upper limit: No established upper limit; studies have used up to 1500mg/day without serious adverse effects

Timing & Absorption

Between meals; throat spray as needed for sore throat symptoms

Can be taken with or without food.

Full Propolis Guide

References

  1. RCTCohen HA, Varsano I, Kahan E, Sarrell EM, Uziel Y (2004). Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children. Archives of Pediatrics & Adolescent Medicine. DOI PubMed
  2. ReviewSforcin JM (2007). Propolis and the immune system: a review. Journal of Ethnopharmacology. DOI PubMed
  3. Chang YC, Porreca A, Massafra R, Lin GM, et al. (2025). Exploring the Effects of Propolis on Oral Mucositis in Patients Undergoing Chemotherapy: A Systematic Review and Meta-Analysis.. Endocrine, metabolic & immune disorders drug targets. DOI PubMed
  4. Bahari H, Shahraki Jazinaki M, Goudarzi K, Namkhah Z, et al. (2025). Effects of propolis consumption on blood pressure, lipid profile and glycemic parameters in adults: a GRADE-assessed systematic review and dose-response meta-analysis.. The British journal of nutrition. DOI PubMed
  5. Qu H, Cao L, Wen Z, Li C, et al. (2025). The effect of propolis supplementation on blood pressure: a systematic review and meta-analysis of controlled trials.. Minerva cardiology and angiology. DOI PubMed
  6. Meta-analysisZhong-Yong L, ZHi-Qing D, Li-Qiong X, Poorasadollah E, et al. (2024). The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials.. Prostaglandins & other lipid mediators. DOI PubMed
  7. Meta-analysisGholami A, Dinarvand N, Hariri M (2024). Propolis supplementation can reduce serum level of interleukin-6, C-reactive protein, and tumor necrosis factor-α: an updated systematic review and dose-response meta-analysis on randomized clinical trials.. Journal of health, population, and nutrition. DOI PubMed
Show 4 more references
  1. Adeli S, Maroofi M, Pourteymour Fard Tabrizi F, Alipour B, et al. (2024). Effects of Propolis Consumption on Glycemic Indices and Liver Enzymes in Adults: A Grading of Recommendations Assessment, Development, and Valuation-assessed Systematic Review and Dose-Response Meta-analysis.. Clinical therapeutics. DOI PubMed
  2. Machado Velho JC, França TA, Malagutti-Ferreira MJ, Albuquerque ER, et al. (2023). Use of propolis for skin wound healing: systematic review and meta-analysis.. Archives of dermatological research. DOI PubMed
  3. Sales-Peres SHC, Azevedo-Silva LJ, Castilho AVSS, Castro MS, et al. (2023). Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis.. Brazilian oral research. DOI PubMed
  4. Meta-analysisNazari-Bonab H, Jamilian P, Radkhah N, Zarezadeh M, et al. (2023). The effect of propolis supplementation in improving antioxidant status: A systematic review and meta-analysis of controlled clinical trials.. Phytotherapy research : PTR. DOI PubMed