Skip to main content
SupplementScience

Sulforaphane Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • GI symptoms (gas, bloating, diarrhea) — the most common side effect, typical of cruciferous compounds
  • Thyroid concerns — high doses of cruciferous isothiocyanates may theoretically interfere with iodine uptake; likely insignificant at supplement doses with adequate iodine intake
  • Sulfurous taste and odor (burping)
  • Generally well-tolerated in clinical trials

Drug & Supplement Interactions

  • Thyroid medications — theoretical interaction with iodine uptake at very high doses; likely insignificant at standard supplement doses
  • CYP1A2 substrates — sulforaphane induces CYP1A2, potentially reducing blood levels of caffeine, theophylline, and some antidepressants
  • Acetaminophen — sulforaphane enhances phase II detoxification which processes acetaminophen; may alter its metabolism

Maximum Dose

Do not exceed: 120mg/day (limited safety data above this level)

Full Sulforaphane Guide

References

  1. (). Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prevention Research. DOI
  2. (). Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine. DOI
  3. (). Sulforaphane treatment of autism spectrum disorder (ASD). Proceedings of the National Academy of Sciences. DOI