General Dosage
150-250mg UMP daily, or 25-50mg triacetyluridine
Maximum dose: 500mg UMP/day or 100mg TAU/day (limited long-term safety data at higher doses)
Uridine Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 150-250mg UMP daily, or 25-50mg triacetyluridine
Timing: Morning or early afternoon with a fat-containing meal; take with DHA and choline for synergy • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Cognitive enhancement | 150-250mg UMP daily | Emerging |
| Mood support | 150-250mg UMP with DHA and choline | Emerging |
| Synaptogenesis (stack) | 250mg UMP + 1000mg DHA + 300mg Alpha-GPC daily | Emerging |
Upper limit: 500mg UMP/day or 100mg TAU/day (limited long-term safety data at higher doses)
Timing & Absorption
Morning or early afternoon with a fat-containing meal; take with DHA and choline for synergy
Best taken with food for optimal absorption.
References
- Wurtman RJ, Cansev M, Sakamoto T, Ulus IH (2009). Use of phosphatide precursors to promote synaptogenesis. Annual Review of Nutrition. DOI PubMed
- Cansev M, Watkins CJ, van der Beek EM, Wurtman RJ (2005). Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Research. DOI PubMed
- Jensen JE, Daniels M, Reppermund S, et al. (2008). Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients. Experimental and Clinical Psychopharmacology.