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Vitamin B5 (Pantothenic Acid) Research & Evidence

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Evidence Level

Moderate

Pantothenic acid's role in CoA synthesis is well-established biochemistry. For lipid management, Rumberger et al. (2011) conducted a multi-center RCT showing pantethine 900 mg/day significantly reduced total cholesterol by 11%, LDL by 12%, and triglycerides by 17% in low to moderate cardiovascular risk subjects. Proksch and de Bony (2006) demonstrated that topical dexpanthenol accelerated skin barrier recovery and reduced transepidermal water loss, supporting its widespread dermatological use. The acne claims associated with high-dose B5 (Dr. Leung's 1997 hypothesis) remain poorly supported by rigorous clinical trials.

Evidence by Condition

ConditionStudied DoseEvidence
General health5-10 mg daily (usually obtained from diet)Strong
Cholesterol support300 mg pantethine three times daily (900 mg total)Moderate
Acne (high dose)2-10 g daily pantothenic acid (limited evidence)Preliminary
Full Vitamin B5 (Pantothenic Acid) Guide

References

  1. (). Pantethine, a derivative of vitamin B5 used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects. Nutrition Research. DOI
  2. (). Topical use of dexpanthenol: a 70th anniversary article. Journal of Dermatological Treatment. DOI
  3. (). Pantothenic acid deficiency as the pathogenesis of acne vulgaris. Medical Hypotheses. DOI