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Types of Vitamin B5 (Pantothenic Acid): Forms & Bioavailability

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
Calcium D-PantothenateHighGeneral supplementation — most common and stable supplement form
PantethineHighCholesterol support — the biologically active form of B5, studied for lipid-lowering effects
Dexpanthenol (Panthenol)TopicalSkin healing and hydration — used topically, converts to pantothenic acid in the skin

Calcium D-Pantothenate

Bioavailability: High. Best for: General supplementation — most common and stable supplement form.

Pantethine

Bioavailability: High. Best for: Cholesterol support — the biologically active form of B5, studied for lipid-lowering effects.

Dexpanthenol (Panthenol)

Bioavailability: Topical. Best for: Skin healing and hydration — used topically, converts to pantothenic acid in the skin.

Full Vitamin B5 (Pantothenic Acid) Guide

References

  1. RCTRumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M (2011). Pantethine, a derivative of vitamin B5 used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects. Nutrition Research. DOI PubMed
  2. ReviewLeung LH (1997). Pantothenic acid deficiency as the pathogenesis of acne vulgaris. Medical Hypotheses. DOI PubMed