Four Sigmatic Organic Cold Brew Coffee Grounds | Dark Roast, Coarse Grounds with Lion's Mane and Chaga | Cold Brew Mushroom Coffee for Crash-Free Focus | 12 oz Bag
$1.20/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
250mg Lion's Mane fruiting body + Yacon root per serving of Lion's Mane + Yacon per ground coffee (coarse) from Four Sigmatic. Best for cold brew enthusiasts — coarse grind…
Why we recommend this
The only purpose-built mushroom coffee for cold brew on the market. Coarse grind prevents over-extraction and bitterness that fine-grind coffee develops during long steeps. Yacon prebiotic adds a gut-support angle unique in the cold brew category.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
The coarse grind is a single-purpose format — unusable in drip machines or espresso. Cold brew also requires planning 12-24 hours ahead.
Dose & form
- Serving
- 250mg Lion's Mane fruiting body + Yacon root per serving
- Form
- Ground Coffee (Coarse)
- Clinical range
- No established clinical dose for mushroom coffee blends
- Dose adequacy
- Blend
- Supply
- 12 servings · $1.20/serving
- UPC
- 816897023349
Who it's best for
Cold brew enthusiasts — coarse grind optimized for slow-steep extraction with Lion's Mane + Yacon
Who should skip it
Hot-drip coffee drinkers — the coarse grind is too large for paper filters and auto-drip machines
Pros
- Coarse grind size optimized for cold brew extraction
- 250mg Lion's Mane + Yacon prebiotic per serving
- Single-origin Honduran Fair Trade beans
- Lower effective caffeine (50mg) — cold brew extracts differently than hot
Cons
- Only works for cold brew — too coarse for drip or espresso
- Only 2 key botanicals (Lion's Mane + Yacon)
- Requires 12-24 hour steep time before drinking
What customers say
4.5★ across 481 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Lion's Mane + Yacon?
What is the clinical dose for Lion's Mane + Yacon?
Clinical trials typically use No established clinical dose for mushroom coffee blends. Four Sigmatic Cold Brew Coffee Grounds delivers 250mg Lion's Mane fruiting body + Yacon root per serving, which we classify as Blend relative to that range.
How does Four Sigmatic Cold Brew Coffee Grounds compare to similar Ground Coffee (Coarse)?
How does Four Sigmatic Cold Brew Coffee Grounds compare to similar Ground Coffee (Coarse)?
See the "Also consider" section below for two alternatives. Choose based on form preference (Ground Coffee (Coarse) vs alternatives), dose adequacy, and third-party testing.
Is Four Sigmatic Cold Brew Coffee Grounds third-party tested?
Is Four Sigmatic Cold Brew Coffee Grounds third-party tested?
Yes — USDA Organic, Fair Trade. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Lion's Mane may mildly affect blood sugar and blood clotting — consult your doctor if on diabetes medications or blood thinners. The 50mg caffeine per serving is mild. Yacon is a prebiotic fiber with no known drug interactions.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Lion's Mane at 250mg daily is well tolerated in clinical studies up to 16 weeks. Yacon's prebiotic fibers may cause mild initial GI adjustment (gas, bloating) in first week of use. No long-term concerns at daily-use doses.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Yacon can cause gas or bloating in people new to high-fiber prebiotics. Starting with one serving daily for the first week allows adaptation. Cold brew coffee itself is lower in acidity than hot brew, so it's gentler on sensitive stomachs.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Yes — works well with most daily supplements. Yacon fiber may enhance probiotic supplement efficacy (prebiotic + probiotic synergy). Cold brew's lower acidity means less interference with iron and calcium supplement absorption than hot coffee.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Use 1.5-2 cups of grounds per quart of cold water; steep 12-18 hours at room temperature or 24 hours in fridge; strain through cheesecloth or fine mesh. Drink within 2 weeks of brewing. Avoid within 6 hours of bedtime despite lower caffeine.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Caffeine alertness and prebiotic gut effects are same-day. Lion's Mane cognitive benefits build over 2-4 weeks of daily use. Yacon gut-microbiome effects show within 7-14 days of consistent intake.
