Four Sigmatic Mushroom Coffee K-Cups | Organic Dark Roast Coffee with Lion’s Mane Mushroom Powder & Yacon | Focus & Immune Support | Vegan & Keto | Sustainable Pods | 24 Count
$1.39/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
250mg Lion's Mane fruiting body + Yacon root per pod of Lion's Mane + Yacon per k-cup pod from Four Sigmatic. Best for keurig owners wanting single-serve mushroom coffee with…
Why we recommend this
The most convenient format for entering mushroom coffee — drop a pod in your Keurig, no grinders or measuring. Yacon prebiotic is a smart pairing for gut-focus users.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
Single-mushroom formula (Lion's Mane only) is narrower than the flagship ground's Lion's Mane + Chaga blend, and pod waste is higher than brewed grounds.
Dose & form
- Serving
- 250mg Lion's Mane fruiting body + Yacon root per pod
- Form
- K-Cup Pod
- Clinical range
- 1-2 cups daily (250-1500mg mushroom extract per serving)
- Dose adequacy
- Therapeutic
- Supply
- 24 servings · $1.39/serving
- UPC
- 816897022175
Who it's best for
Keurig owners wanting single-serve mushroom coffee with 250mg Lion's Mane + prebiotic Yacon per pod
Who should skip it
Value-focused buyers — per-cup cost runs about 2x loose-ground mushroom coffee
Pros
- 250mg Lion's Mane per pod — full adaptogen dose per serving
- Organic Yacon prebiotic supports gut health alongside focus
- Lower caffeine (100mg) than standard K-Cups — less jitter risk
- 6,727+ reviews and 4.4 stars; fits any Keurig
Cons
- Only Lion's Mane (no Chaga like the ground version)
- K-Cup format generates more waste than bulk grounds
- Premium price — about $1.39/pod vs $0.40 for standard K-Cups
What customers say
4.4★ across 6,727 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Lion's Mane + Yacon?
What is the clinical dose for Lion's Mane + Yacon?
Clinical trials typically use 1-2 cups daily (250-1500mg mushroom extract per serving). Four Sigmatic Focus K-Cups (24ct) delivers 250mg Lion's Mane fruiting body + Yacon root per pod, which we classify as Therapeutic relative to that range.
How does Four Sigmatic Focus K-Cups (24ct) compare to similar K-Cup Pod?
How does Four Sigmatic Focus K-Cups (24ct) compare to similar K-Cup Pod?
See the "Also consider" section below for two alternatives. Choose based on form preference (K-Cup Pod vs alternatives), dose adequacy, and third-party testing.
Is Four Sigmatic Focus K-Cups (24ct) third-party tested?
Is Four Sigmatic Focus K-Cups (24ct) third-party tested?
Yes — USDA Organic, Single Origin. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Lion's Mane may mildly lower blood sugar and affect blood clotting — consult your doctor if on diabetes medications or blood thinners. The 100mg caffeine per pod is half a typical cup and well-tolerated alongside most medications. Yacon is a prebiotic fiber with no known drug interactions.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Lion's Mane at 250mg daily is well tolerated in clinical trials up to 16 weeks. Yacon may cause mild gas or bloating in sensitive individuals due to its prebiotic fibers. Long-term coffee consumption hygiene applies — avoid late-day consumption to protect sleep.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Yacon's prebiotic fiber content can cause mild gas or bloating in people new to high-fiber intake. Starting with one pod per day allows the gut microbiome to adjust. The Lion's Mane fruiting body is generally easy on digestion — no grain-based fillers.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Yes — pairs well with most daily supplements. Yacon's prebiotic fiber may enhance the effect of probiotics taken later in the day. Avoid stacking with additional caffeine sources (pre-workouts, energy drinks) to stay under 400mg daily caffeine.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Use in any Keurig-compatible brewer. One pod per serving. Avoid within 6 hours of bed due to caffeine (100mg). If you're new to prebiotics, start with one pod daily for the first week to allow gut adaptation.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Caffeine and prebiotic benefits are immediate to same-day. Lion's Mane cognitive effects build over 2-4 weeks of daily use, consistent with clinical research dosing. Gut health effects from Yacon appear within 7-14 days of consistent intake.
Also consider
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