Integrative Therapeutics K2 + D3 - Supplement for Heart Health & Bone Strength* - Daily Vitamins for Calcium Absorption - Supports Vitality - Dairy-Free & Gluten-Free - 60 Count (60 Servings)

Clinical trials typically use Vitamin K2 (MK-7): 100-360mcg/day in clinical bone and cardiovascular trials; Vitamin D3: 1000-5000 IU/day for maintenance and repletion in most adult populations.. Integrative Therapeutics K2 + D3 delivers 1 capsule per serving (60 servings per bottle), which we classify as MenaQ7 is clinically validated in the landmark 3-year Knapen et al. trial at 180mcg/day for bone and arterial health. Vitamin D3 at 5000 IU represents a therapeutic dose appropriate for many adults with baseline deficiency. The combination at these amounts is well within the range used in peer-reviewed human trials, making dose adequacy high for both key nutrients. relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.

Yes — Third-Party Tested. Third-party testing verifies ingredient identity and label accuracy.

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Vitamin K2 has a significant interaction with warfarin (Coumadin) and other vitamin K-antagonist anticoagulants — even small changes in vitamin K intake can shift INR levels and alter anticoagulant effectiveness. Individuals taking blood thinners must consult their physician or pharmacist before adding any K2 supplement. Vitamin D3 at doses above 2000 IU may also interact modestly with thiazide diuretics by increasing calcium absorption; patients on these medications should monitor calcium levels.

Long-term use of vitamin K2 (MK-7) at 100-360mcg/day has been studied in clinical trials up to 3 years with no identified safety concerns in healthy adults. Vitamin D3 supplementation is safe long-term when kept within established upper limits (generally 4000 IU/day for most adults per the Institute of Medicine, though many practitioners use higher doses with monitoring). Integrative Therapeutics recommends periodic vitamin D level testing (25-OH-D blood test) to ensure you remain within the optimal range.

Both vitamin K2 (MK-7) and vitamin D3 are generally well tolerated with minimal GI side effects. A small number of users report mild nausea if D3 is taken on an empty stomach; taking K2 + D3 with a fat-containing meal virtually eliminates this issue and also enhances absorption of these fat-soluble vitamins. No meaningful GI tolerability issues have been reported in clinical trials of MenaQ7 at standard doses.

K2 + D3 pairs well with magnesium (which is required for vitamin D activation in the body) and calcium supplements, where the K2 specifically helps direct absorbed calcium to bone. Avoid combining with other high-dose fat-soluble vitamins (A, E) without tracking total fat-soluble vitamin intake to prevent accumulation. Compatible with standard daily multivitamins, omega-3s, and most common supplement stacks.

Take 1 capsule daily with a fat-containing meal, as both D3 and K2 are fat-soluble vitamins that require dietary lipids for absorption. Individuals on anticoagulant therapy must consult their physician before starting. Have your 25-OH-D level tested before supplementing and retest after 3 months of consistent use to confirm you are in the optimal range (typically 40-80 ng/mL). Follow label directions or your healthcare provider's personalized guidance.

Vitamin D3 deficiency correction is measurable within 4-8 weeks of consistent supplementation as serum 25-OH-D levels rise. The bone density and arterial health benefits of MenaQ7 K2 are cumulative and long-term — the landmark MenaQ7 clinical trial measured statistically significant bone and arterial improvements over 3 years. Short-term, many users with low baseline D levels report improved energy and mood within 4-8 weeks as vitamin D status normalizes.