Integrative Therapeutics
Integrative Therapeutics is a clinical-grade supplement brand founded in 1979 in Green Bay, Wisconsin, and now a division of Schwabe Extracta (acquired 2014). The brand was built for licensed healthcare professionals — physicians, naturopaths, and functional medicine practitioners — and remains one of the most trusted practitioner-channel lines in North America. Core categories include adrenal/stress support, gastrointestinal health, metabolic and cardiovascular function, and immune regulation. Flagship products include SBI Protect (secretory IgG), Cortisol Manager, Berberine 500, and the Pro-Flora MAX probiotic line. All formulations are GMP certified, carry clean-label sourcing commitments, and are grounded in peer-reviewed science rather than marketing trends. With 93 SKUs, Integrative Therapeutics represents one of the broadest clinical-grade catalogs available to consumers through practitioner recommendation.
Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations...
Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations with disclosed ingredient dosing, GMP-certified manufacturing, and a 45-year track record of healthcare professional trust.
Browse Products
Integrative Therapeutics Cortisol Manager
2 tablets per serving, 15 servings per bottle (taken as directed, typically at bedtime) per tablet · Ashwagandha (KSM-66 or equivalent) and L-theanine
Cortisol Manager is Integrative Therapeutics' flagship stress-and-sleep formula, combining ashwagandha and L-theanine — two of the most rigorously studied adaptogens and amino acids for cortisol modulation and relaxation — into a single clinical-grade tablet. Named best overall ashwagandha supplement by Vogue, it addresses the root mechanism of stress-disrupted sleep: elevated evening cortisol that prevents winding down. With 10,315 Amazon reviews and a 4.3-star rating, it is one of the most reviewed and validated practitioner-brand supplements in the stress-support category. Integrative Therapeutics has produced GMP-certified, clinician-trusted supplements since 1979.
Integrative Therapeutics Active B-Complex
2 capsules per serving (60 capsules, 30 servings) per capsule · Active B2, B6, B12 + Methylfolate + Choline
Clinical-grade active B-complex featuring methylated and coenzyme forms of B2, B6, B12, plus choline and methylfolate. Supports cellular energy, neurotransmitter synthesis, and immune function. Gluten-free and dairy-free.
Integrative Therapeutics Berberine
Berberine per capsule (60 capsules, 60 servings) per capsule · Berberine HCl
Practitioner-trusted berberine supplement for metabolic support, providing clinically-studied berberine HCl in a clean, allergen-free capsule free of wheat, gluten, corn, soy, dairy, and artificial additives. GMP certified by Integrative Therapeutics since 1979.
Integrative Therapeutics Theracurmin HP
Theracurmin per serving (60 capsules, 30 servings) per capsule · Theracurmin (Bioavailable Curcumin Complex)
Clinically-studied bioavailable curcumin supplement using Theracurmin technology for 27x greater absorption than standard curcumin extract. Supports post-workout muscle recovery, cardiovascular function, and joint health in a dairy-free, gluten-free capsule.
IT Tri-Magnesium Triple-Form Capsules (90ct)
1 capsule per serving; 90 servings per 90-count bottle per capsule · Tri-Magnesium complex (multiple magnesium forms)
90-capsule tri-form magnesium complex with 2,394 reviews at 4.7 stars, supporting cellular energy, stress response, nerve function, bone, and heart health.
IT Buffered Vitamin C 1000mg Capsules (60ct)
1000mg vitamin C (buffered) per capsule; 1 capsule daily per capsule · Buffered Vitamin C 1000mg per capsule
60 capsules of buffered vitamin C (1000mg per capsule) for immune support, collagen, and antioxidant protection. 2,146 reviews at 4.8 stars. Vegan, gluten-free.
Integrative Therapeutics Lavela WS 1265
1 softgel per serving, 60 servings per softgel · Silexan (oral lavender essential oil, WS 1265)
Clinically studied Silexan oral lavender essential oil shown to reduce anxiety and improve sleep quality without sedation or dependency risk.
Integrative Therapeutics Cortisol Manager Allergen Free
2 capsules per serving; 15 servings per 30-capsule bottle per capsule · Ashwagandha + L-Theanine + Phosphatidylserine
Allergen-free adrenal support capsule combining ashwagandha (Withania somnifera) with L-theanine and phosphatidylserine to support healthy cortisol balance, stress response, and restful sleep. Vegan, gluten-free, dairy-free, and free of all top-9 US allergens. 30 capsules per bottle (15 servings). GMP-manufactured by Integrative Therapeutics since 1979.
IT L-Theanine 200mg Stress Capsules (60ct / 30srv)
200mg L-Theanine per serving (2 capsules); 30 servings per 60-count bottle per capsule · L-Theanine 200mg per serving (100mg per capsule)
60 capsules delivering 200mg L-Theanine per 2-capsule serving for stress response, relaxation, and calm focus support. 1,534 reviews at 4.6 stars. Vegan, gluten-free.
IT NAC N-Acetyl L-Cysteine Capsules (60ct)
1 capsule per serving; dose per capsule not specified in Amazon listing per capsule · N-Acetyl L-Cysteine (NAC)
60 capsules of N-Acetyl L-Cysteine (NAC) for glutathione precursor, respiratory health, and antioxidant support. 1,463 reviews at 4.7 stars. Gluten-free, dairy-free.
Integrative Therapeutics Activated Charcoal
2 capsules per serving, 50 servings per capsule · Activated Charcoal (coconut husk)
Coconut husk-sourced activated charcoal in clinical-grade capsules to adsorb and eliminate unwanted gut substances and support digestive wellness.
Integrative Therapeutics HPA Adapt
1 capsule per serving (120 capsules, 120 servings per bottle) per capsule · Sensoril Ashwagandha + Rhodiola Root Extract + Eleuthero + Maca + Holy Basil
Clinical-grade multi-adaptogen formula combining Sensoril ashwagandha, rhodiola, eleuthero, maca, and holy basil to support HPA axis function, healthy stress hormone balance, and a calm, positive stress response. Vegan, gluten-free, and dairy-free.
IT Lipase Concentrate-HP (90ct / 45 Servings)
2 capsules per serving; 45 servings per 90-count bottle per capsule · Lipase (microbial, high-potency concentrate)
pH-stable lipase enzyme concentrate for fat digestion and GI tract support, active in both acid and alkaline conditions. 90 capsules, 45 servings, dairy-free and vegan.
Integrative Therapeutics Zinc-Carnosine
75 mg zinc-carnosine (delivering 16 mg elemental zinc) per capsule per capsule · PepZinGI (Zinc-Carnosine Complex)
Patented PepZinGI zinc-carnosine complex delivering 16 mg zinc per capsule for GI mucosal support. Vegan, gluten-free, no animal ingredients.
IT DHEA-5 5mg Capsules (60ct)
5mg DHEA per capsule; 1 capsule daily per capsule · DHEA (dehydroepiandrosterone) 5mg
5mg DHEA capsules supporting healthy aging and adrenal hormone balance, with 952 reviews. Vegan, gluten-free, and dairy-free from Integrative Therapeutics.
Integrative Therapeutics Liquid Calcium Magnesium
1 tablespoon (15 mL) once daily with food (32 servings per 16 oz bottle) per liquid · Calcium Citrate + Magnesium Citrate + Vitamin D (400 IU)
Liquid calcium-magnesium supplement in a 2:1 citrate ratio with 400 IU vitamin D per serving. Orange vanilla flavored, sugar-free, gluten-free, and dairy-free. Designed for bone health support and easy daily compliance.
IT Similase Digestive Enzymes
2 capsules per serving (90 capsules, 45 servings) per capsule · Microbial-source digestive enzyme blend
Vegan microbial digestive enzyme blend active across a broad pH range to support digestion and nutrient assimilation. Dairy-free, 90 capsules (45 servings).
Integrative Therapeutics Similase GFCF
Microbial enzyme blend per 2-capsule serving (120 capsules, 60 servings) per capsule · DPP IV-Active Microbial Enzyme Blend (Protease with DPP IV Activity)
Clinical-grade digestive enzyme capsule formulated specifically to support dipeptidyl peptidase IV (DPP IV) activity for digestion of proline-containing dipeptides from gluten and casein. Vegan, dairy-free, and designed for adults with GFCF sensitivity.
IT Liquid Calcium Magnesium Berry
Calcium and magnesium in 1:1 ratio per 15 mL serving with vitamin D3 per liquid · Calcium + Magnesium (1:1 ratio) + Vitamin D3
Berry-flavoured liquid delivering a 1:1 calcium-to-magnesium ratio plus vitamin D3 for bone support. Sugar-free, gluten-free, dairy-free. 32 servings per bottle.
IT Pro-Flora Women's Probiotic 30ct
1 capsule per serving (30 servings per bottle) per capsule · Lactobacillus rhamnosus GR-1 + Lactobacillus reuteri RC-14
Shelf-stable women's probiotic with clinically studied Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 for urogenital health.
Integrative Therapeutics Riboflavin B2 Vitamin
Riboflavin (B2) per tablet (30 tablets, 30 servings at 1 tablet/day); product weight listed as 400 mg per tablet per tablet · Riboflavin (Vitamin B2)
Clinical-grade riboflavin (vitamin B2) tablet from Integrative Therapeutics supporting cellular energy, red blood cell production, and enzymatic cofactors. Vegan, gluten-free.
IT Vitamin D3 125 mcg Chewable
125 mcg (5,000 IU) vitamin D3 per chewable tablet (90 tablets, 90 servings) per chewable tablet · Vitamin D3 (cholecalciferol) 5,000 IU
High-potency 5,000 IU (125 mcg) vitamin D3 as cholecalciferol in a chocolate-flavored chewable tablet. Supports calcium absorption, bone health, and immune function. Gluten-free, dairy-free, sugar-free. Clinical-grade Integrative Therapeutics formulation.
Integrative Therapeutics Probiotic Pearls
Probiotic blend per pearl capsule (30 count, 30 servings at 1 capsule/day) per capsule · Probiotic Blend (Lactobacillus + Bifidobacterium)
Clinical-grade pearl-form probiotic from Integrative Therapeutics with Lactobacillus and Bifidobacterium for daily gut and immune support. Soy-free.
IT B12-Active Methylcobalamin Chewable
1 chewable tablet per serving, methylcobalamin form (30 tablets, 30 servings) per chewable · Methylcobalamin (active B12)
Methylcobalamin B12 cherry chewable using the active bioavailable form requiring no body conversion. Gluten-free, soy-free, dairy-free. 30 tablets.
Frequently Asked Questions
Do I need a doctor to buy Integrative Therapeutics products?
Do I need a doctor to buy Integrative Therapeutics products?
Traditionally, Integrative Therapeutics sold exclusively through licensed healthcare professionals (physicians, naturopaths, functional medicine practitioners). Today, most SKUs are also available through Amazon and third-party retailers without a prescription. However, the brand still recommends professional supervision, especially for condition-specific products like Cortisol Manager or SBI Protect, because dosing and selection decisions benefit from clinical guidance.
Is Integrative Therapeutics a reputable brand?
Is Integrative Therapeutics a reputable brand?
Yes — Integrative Therapeutics has a 45-year track record as a practitioner-trusted brand. Since its 1979 founding and its 2014 acquisition by Schwabe Extracta (one of the world's largest herbal medicine manufacturers), the brand has maintained GMP-certified manufacturing, science-backed formulations, and a professional-channel distribution model that self-selects for clinicians who demand quality evidence for their patients.
How does Cortisol Manager work and is it effective?
How does Cortisol Manager work and is it effective?
Cortisol Manager combines Ashwagandha (Sensoril standardized extract), Phosphatidylserine, and L-Theanine to modulate the cortisol stress response and support sleep onset. Clinical evidence for Ashwagandha at standardized doses is solid (KSM-66 and Sensoril both have RCT support), and Phosphatidylserine has strong evidence for blunting exercise-induced cortisol. It's one of the brand's most clinically credentialed products.
What is SBI Protect and who should take it?
What is SBI Protect and who should take it?
SBI Protect delivers 500mg of serum-derived bovine immunoglobulins (secretory IgG) per serving — a unique ingredient that binds and neutralizes gut pathogens, supports gut-barrier integrity, and modulates intestinal immune activity. It's primarily used under practitioner guidance for leaky gut, IBS, inflammatory bowel concerns, and post-antibiotic gut restoration. It is not a standard probiotic — it works via immune-passthrough rather than bacterial colonization.
What is the difference between Integrative Therapeutics and typical store-brand supplements?
What is the difference between Integrative Therapeutics and typical store-brand supplements?
The key differences are formulation intent and channel. Integrative Therapeutics designs products to meet clinical scrutiny — licensed healthcare professionals will not recommend products that under-dose or use proprietary blends they can't justify to patients. This drives the brand to use clinically researched doses, disclose ingredient amounts, and maintain GMP manufacturing. Retail brands are optimized for shelf presence and price; Integrative Therapeutics is optimized for clinical defensibility.
As an Amazon Associate, we earn from qualifying purchases. Some links below are affiliate links — this doesn't affect our editorial independence or product ratings. How we evaluate products
This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer























