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Science-Verified Brand

Integrative Therapeutics

Integrative Therapeutics is a clinical-grade supplement brand founded in 1979 in Green Bay, Wisconsin, and now a division of Schwabe Extracta (acquired 2014). The brand was built for licensed healthcare professionals — physicians, naturopaths, and functional medicine practitioners — and remains one of the most trusted practitioner-channel lines in North America. Core categories include adrenal/stress support, gastrointestinal health, metabolic and cardiovascular function, and immune regulation. Flagship products include SBI Protect (secretory IgG), Cortisol Manager, Berberine 500, and the Pro-Flora MAX probiotic line. All formulations are GMP certified, carry clean-label sourcing commitments, and are grounded in peer-reviewed science rather than marketing trends. With 93 SKUs, Integrative Therapeutics represents one of the broadest clinical-grade catalogs available to consumers through practitioner recommendation.

Founded 1979Green Bay, Wisconsin93 products
Third-Party TestedNo Proprietary BlendsClinical DosingPublished COAs

Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations...

Integrative Therapeutics earns Science-Verified designation for its clinical-grade, practitioner-backed formulations with disclosed ingredient dosing, GMP-certified manufacturing, and a 45-year track record of healthcare professional trust.

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All 93Digestive Enzymes 6Digestive Support 4Probiotic Supplements 3Omega-3 / Fish Oil 3Bone Health 2Immune Support 2CoQ10 Supplements 2Digestive Enzyme Supplements 2Respiratory Support 2Hormone & Aging Support 2Mineral Support 2Vitamin D Supplements 2Berberine Supplements 2Iron Supplements 1Vitamin C 1Multivitamins 1Women's Hormonal Health 1Liver Detox Support 1B Vitamins 1Mood & Sleep Support 1Vitamin B12 1Detox & Hormonal Support 1Digestive Fiber & Colon Support 1Antioxidants & Heart Health 1Stress & Sleep 1Men's Health 1Liver Support 1Brain & Nerve Health 1Heart & Energy Support 1Antioxidant & Immune Support 1Heart & Cellular Energy Support 1Antioxidant & Respiratory Support 1Stress Support 1Amino Acid Supplements 1B Vitamin Supplements 1Joint Support Supplements 1Brain & Neurological Support Supplements 1Brain & Cognitive Support 1Joint & Movement Support 1Digestive & Gut Health 1Sleep & Stress Support 1Digestive Health & Probiotics 1B-Complex Supplements 1Calcium Supplements 1Quercetin Supplements 1Adaptogen Supplements 1Sleep Supplements 1Antioxidant Supplements 1Multivitamin Supplements 1Turmeric Supplements 1Nootropic Supplements 1Hormone Balance Support 1Antioxidant & Heart Health 1Digestive & Colon Support 1Minerals 1Antioxidants 1Probiotics 1Amino Acids / Gut Health 1Gut Health / Zinc 1Bone Health / Minerals 1Iron Supplement 1Seasonal Immune Support 1GI Motility Support 1Adrenal & Stress Support 1Sleep Support 1Multivitamin 1Nootropic 1Zinc 1Probiotic 1Antioxidant & Anti-Inflammatory 1Bone & Cardiovascular Health 1Cognitive Health & Brain Function 1
Stress & SleepTablet

Integrative Therapeutics Cortisol Manager

Third-Party Tested

2 tablets per serving, 15 servings per bottle (taken as directed, typically at bedtime) per tablet · Ashwagandha (KSM-66 or equivalent) and L-theanine

Cortisol Manager is Integrative Therapeutics' flagship stress-and-sleep formula, combining ashwagandha and L-theanine — two of the most rigorously studied adaptogens and amino acids for cortisol modulation and relaxation — into a single clinical-grade tablet. Named best overall ashwagandha supplement by Vogue, it addresses the root mechanism of stress-disrupted sleep: elevated evening cortisol that prevents winding down. With 10,315 Amazon reviews and a 4.3-star rating, it is one of the most reviewed and validated practitioner-brand supplements in the stress-support category. Integrative Therapeutics has produced GMP-certified, clinician-trusted supplements since 1979.

4.3 (10,315)
$26.75$0.89/serving
B-Complex SupplementsCapsule

Integrative Therapeutics Active B-Complex

GMP Certified

2 capsules per serving (60 capsules, 30 servings) per capsule · Active B2, B6, B12 + Methylfolate + Choline

Clinical-grade active B-complex featuring methylated and coenzyme forms of B2, B6, B12, plus choline and methylfolate. Supports cellular energy, neurotransmitter synthesis, and immune function. Gluten-free and dairy-free.

4.6 (7,478)
$18.25$0.30/serving
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Berberine SupplementsCapsule

Integrative Therapeutics Berberine

GMP Certified

Berberine per capsule (60 capsules, 60 servings) per capsule · Berberine HCl

Practitioner-trusted berberine supplement for metabolic support, providing clinically-studied berberine HCl in a clean, allergen-free capsule free of wheat, gluten, corn, soy, dairy, and artificial additives. GMP certified by Integrative Therapeutics since 1979.

4.5 (3,614)
$32.75$0.55/serving
Turmeric SupplementsCapsule

Integrative Therapeutics Theracurmin HP

GMP Certified

Theracurmin per serving (60 capsules, 30 servings) per capsule · Theracurmin (Bioavailable Curcumin Complex)

Clinically-studied bioavailable curcumin supplement using Theracurmin technology for 27x greater absorption than standard curcumin extract. Supports post-workout muscle recovery, cardiovascular function, and joint health in a dairy-free, gluten-free capsule.

4.6 (2,638)
$56.00$0.93/serving
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Mineral SupportCapsule

IT Tri-Magnesium Triple-Form Capsules (90ct)

GMP Certified

1 capsule per serving; 90 servings per 90-count bottle per capsule · Tri-Magnesium complex (multiple magnesium forms)

90-capsule tri-form magnesium complex with 2,394 reviews at 4.7 stars, supporting cellular energy, stress response, nerve function, bone, and heart health.

4.7 (2,394)
$21.00$0.23/serving
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Antioxidant & Immune SupportCapsule

IT Buffered Vitamin C 1000mg Capsules (60ct)

GMP Certified

1000mg vitamin C (buffered) per capsule; 1 capsule daily per capsule · Buffered Vitamin C 1000mg per capsule

60 capsules of buffered vitamin C (1000mg per capsule) for immune support, collagen, and antioxidant protection. 2,146 reviews at 4.8 stars. Vegan, gluten-free.

4.8 (2,146)
$15.25$0.25/serving
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Sleep & Stress SupportSoftgel

Integrative Therapeutics Lavela WS 1265

Third-Party Tested

1 softgel per serving, 60 servings per softgel · Silexan (oral lavender essential oil, WS 1265)

Clinically studied Silexan oral lavender essential oil shown to reduce anxiety and improve sleep quality without sedation or dependency risk.

4.4 (2,136)
$37.50$0.63/serving
Adrenal & Stress SupportCapsule

Integrative Therapeutics Cortisol Manager Allergen Free

GMP-manufactured; USA-bottled and tested; manufacturer-verified allergen-free (top 9 US allergens)

2 capsules per serving; 15 servings per 30-capsule bottle per capsule · Ashwagandha + L-Theanine + Phosphatidylserine

Allergen-free adrenal support capsule combining ashwagandha (Withania somnifera) with L-theanine and phosphatidylserine to support healthy cortisol balance, stress response, and restful sleep. Vegan, gluten-free, dairy-free, and free of all top-9 US allergens. 30 capsules per bottle (15 servings). GMP-manufactured by Integrative Therapeutics since 1979.

4.5 (1,951)
$28.50$0.95/serving
Stress SupportCapsule

IT L-Theanine 200mg Stress Capsules (60ct / 30srv)

GMP Certified

200mg L-Theanine per serving (2 capsules); 30 servings per 60-count bottle per capsule · L-Theanine 200mg per serving (100mg per capsule)

60 capsules delivering 200mg L-Theanine per 2-capsule serving for stress response, relaxation, and calm focus support. 1,534 reviews at 4.6 stars. Vegan, gluten-free.

4.6 (1,534)
$22.00$0.37/serving
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Antioxidant & Respiratory SupportCapsule

IT NAC N-Acetyl L-Cysteine Capsules (60ct)

GMP Certified

1 capsule per serving; dose per capsule not specified in Amazon listing per capsule · N-Acetyl L-Cysteine (NAC)

60 capsules of N-Acetyl L-Cysteine (NAC) for glutathione precursor, respiratory health, and antioxidant support. 1,463 reviews at 4.7 stars. Gluten-free, dairy-free.

4.7 (1,463)
$18.00$0.30/serving
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Digestive & Gut HealthCapsule

Integrative Therapeutics Activated Charcoal

Third-Party Tested

2 capsules per serving, 50 servings per capsule · Activated Charcoal (coconut husk)

Coconut husk-sourced activated charcoal in clinical-grade capsules to adsorb and eliminate unwanted gut substances and support digestive wellness.

4.7 (1,401)
$13.75$0.14/serving
Adaptogen SupplementsCapsule

Integrative Therapeutics HPA Adapt

GMP Certified

1 capsule per serving (120 capsules, 120 servings per bottle) per capsule · Sensoril Ashwagandha + Rhodiola Root Extract + Eleuthero + Maca + Holy Basil

Clinical-grade multi-adaptogen formula combining Sensoril ashwagandha, rhodiola, eleuthero, maca, and holy basil to support HPA axis function, healthy stress hormone balance, and a calm, positive stress response. Vegan, gluten-free, and dairy-free.

4.6 (1,356)
$39.50$0.33/serving
Digestive EnzymesCapsule

IT Lipase Concentrate-HP (90ct / 45 Servings)

GMP Certified

2 capsules per serving; 45 servings per 90-count bottle per capsule · Lipase (microbial, high-potency concentrate)

pH-stable lipase enzyme concentrate for fat digestion and GI tract support, active in both acid and alkaline conditions. 90 capsules, 45 servings, dairy-free and vegan.

4.4 (1,338)
$25.25$0.28/serving
Gut Health / ZincCapsule

Integrative Therapeutics Zinc-Carnosine

Bottled and tested in USA; GMP manufactured

75 mg zinc-carnosine (delivering 16 mg elemental zinc) per capsule per capsule · PepZinGI (Zinc-Carnosine Complex)

Patented PepZinGI zinc-carnosine complex delivering 16 mg zinc per capsule for GI mucosal support. Vegan, gluten-free, no animal ingredients.

4.6 (985)
$38.50$0.64/serving
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Hormone & Aging SupportCapsule

IT DHEA-5 5mg Capsules (60ct)

GMP Certified

5mg DHEA per capsule; 1 capsule daily per capsule · DHEA (dehydroepiandrosterone) 5mg

5mg DHEA capsules supporting healthy aging and adrenal hormone balance, with 952 reviews. Vegan, gluten-free, and dairy-free from Integrative Therapeutics.

4.7 (952)
$10.00$0.17/serving
Calcium SupplementsLiquid

Integrative Therapeutics Liquid Calcium Magnesium

GMP Certified

1 tablespoon (15 mL) once daily with food (32 servings per 16 oz bottle) per liquid · Calcium Citrate + Magnesium Citrate + Vitamin D (400 IU)

Liquid calcium-magnesium supplement in a 2:1 citrate ratio with 400 IU vitamin D per serving. Orange vanilla flavored, sugar-free, gluten-free, and dairy-free. Designed for bone health support and easy daily compliance.

4.6 (947)
$25.75$1.61/serving
Digestive EnzymesCapsule

IT Similase Digestive Enzymes

GMP Certified

2 capsules per serving (90 capsules, 45 servings) per capsule · Microbial-source digestive enzyme blend

Vegan microbial digestive enzyme blend active across a broad pH range to support digestion and nutrient assimilation. Dairy-free, 90 capsules (45 servings).

4.6 (904)
$27.00$0.30/serving
Digestive Enzyme SupplementsCapsule

Integrative Therapeutics Similase GFCF

GMP Certified

Microbial enzyme blend per 2-capsule serving (120 capsules, 60 servings) per capsule · DPP IV-Active Microbial Enzyme Blend (Protease with DPP IV Activity)

Clinical-grade digestive enzyme capsule formulated specifically to support dipeptidyl peptidase IV (DPP IV) activity for digestion of proline-containing dipeptides from gluten and casein. Vegan, dairy-free, and designed for adults with GFCF sensitivity.

4.6 (892)
$35.25$0.29/serving
Bone Health / MineralsLiquid

IT Liquid Calcium Magnesium Berry

Tested in USA; GMP manufactured

Calcium and magnesium in 1:1 ratio per 15 mL serving with vitamin D3 per liquid · Calcium + Magnesium (1:1 ratio) + Vitamin D3

Berry-flavoured liquid delivering a 1:1 calcium-to-magnesium ratio plus vitamin D3 for bone support. Sugar-free, gluten-free, dairy-free. 32 servings per bottle.

4.6 (836)
$25.25$1.58/serving
ProbioticsCapsule

IT Pro-Flora Women's Probiotic 30ct

Third-Party Tested

1 capsule per serving (30 servings per bottle) per capsule · Lactobacillus rhamnosus GR-1 + Lactobacillus reuteri RC-14

Shelf-stable women's probiotic with clinically studied Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 for urogenital health.

4.2 (829)
$33.75$1.13/serving
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B Vitamin SupplementsTablet

Integrative Therapeutics Riboflavin B2 Vitamin

GMP Certified

Riboflavin (B2) per tablet (30 tablets, 30 servings at 1 tablet/day); product weight listed as 400 mg per tablet per tablet · Riboflavin (Vitamin B2)

Clinical-grade riboflavin (vitamin B2) tablet from Integrative Therapeutics supporting cellular energy, red blood cell production, and enzymatic cofactors. Vegan, gluten-free.

4.6 (792)
$13.00$0.43/serving
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Vitamin D SupplementsChewable Tablet

IT Vitamin D3 125 mcg Chewable

GMP Certified

125 mcg (5,000 IU) vitamin D3 per chewable tablet (90 tablets, 90 servings) per chewable tablet · Vitamin D3 (cholecalciferol) 5,000 IU

High-potency 5,000 IU (125 mcg) vitamin D3 as cholecalciferol in a chocolate-flavored chewable tablet. Supports calcium absorption, bone health, and immune function. Gluten-free, dairy-free, sugar-free. Clinical-grade Integrative Therapeutics formulation.

4.7 (745)
$23.50$0.26/serving
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Probiotic SupplementsCapsule

Integrative Therapeutics Probiotic Pearls

GMP Certified

Probiotic blend per pearl capsule (30 count, 30 servings at 1 capsule/day) per capsule · Probiotic Blend (Lactobacillus + Bifidobacterium)

Clinical-grade pearl-form probiotic from Integrative Therapeutics with Lactobacillus and Bifidobacterium for daily gut and immune support. Soy-free.

4.6 (715)
$18.25$0.61/serving
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Vitamin B12Chewable

IT B12-Active Methylcobalamin Chewable

GMP Certified

1 chewable tablet per serving, methylcobalamin form (30 tablets, 30 servings) per chewable · Methylcobalamin (active B12)

Methylcobalamin B12 cherry chewable using the active bioavailable form requiring no body conversion. Gluten-free, soy-free, dairy-free. 30 tablets.

4.7 (653)
$11.25$0.38/serving
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Frequently Asked Questions

Do I need a doctor to buy Integrative Therapeutics products?

Traditionally, Integrative Therapeutics sold exclusively through licensed healthcare professionals (physicians, naturopaths, functional medicine practitioners). Today, most SKUs are also available through Amazon and third-party retailers without a prescription. However, the brand still recommends professional supervision, especially for condition-specific products like Cortisol Manager or SBI Protect, because dosing and selection decisions benefit from clinical guidance.

Is Integrative Therapeutics a reputable brand?

Yes — Integrative Therapeutics has a 45-year track record as a practitioner-trusted brand. Since its 1979 founding and its 2014 acquisition by Schwabe Extracta (one of the world's largest herbal medicine manufacturers), the brand has maintained GMP-certified manufacturing, science-backed formulations, and a professional-channel distribution model that self-selects for clinicians who demand quality evidence for their patients.

How does Cortisol Manager work and is it effective?

Cortisol Manager combines Ashwagandha (Sensoril standardized extract), Phosphatidylserine, and L-Theanine to modulate the cortisol stress response and support sleep onset. Clinical evidence for Ashwagandha at standardized doses is solid (KSM-66 and Sensoril both have RCT support), and Phosphatidylserine has strong evidence for blunting exercise-induced cortisol. It's one of the brand's most clinically credentialed products.

What is SBI Protect and who should take it?

SBI Protect delivers 500mg of serum-derived bovine immunoglobulins (secretory IgG) per serving — a unique ingredient that binds and neutralizes gut pathogens, supports gut-barrier integrity, and modulates intestinal immune activity. It's primarily used under practitioner guidance for leaky gut, IBS, inflammatory bowel concerns, and post-antibiotic gut restoration. It is not a standard probiotic — it works via immune-passthrough rather than bacterial colonization.

What is the difference between Integrative Therapeutics and typical store-brand supplements?

The key differences are formulation intent and channel. Integrative Therapeutics designs products to meet clinical scrutiny — licensed healthcare professionals will not recommend products that under-dose or use proprietary blends they can't justify to patients. This drives the brand to use clinically researched doses, disclose ingredient amounts, and maintain GMP manufacturing. Retail brands are optimized for shelf presence and price; Integrative Therapeutics is optimized for clinical defensibility.

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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer