Integrative Therapeutics Vitamin D3 125 mcg - Vitamin D Supplement for Bone Health & Immune Support* - Gluten-Free & Dairy-Free - Chocolate Flavored, 90 Chewable Tablets (90 Servings)

Clinical trials typically use 1,000-4,000 IU daily (25-100 mcg). IT Vitamin D3 125 mcg Chewable delivers 125 mcg (5,000 IU) vitamin D3 per chewable tablet (90 tablets, 90 servings), which we classify as Full relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Chewable Tablet vs alternatives), dose adequacy, and third-party testing.

Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Vitamin D3 at 5,000 IU can interact with thiazide diuretics (increasing hypercalcemia risk), digoxin (affecting heart rhythm at elevated calcium levels), and certain statins that affect D metabolism. Calcitriol (prescription-active D) users should not add D3 supplementation without physician approval. Corticosteroid users may need higher D3 doses due to interference with D absorption.

Vitamin D3 is fat-soluble and can accumulate — long-term supplementation at 5,000 IU daily should be monitored with periodic serum 25-OH vitamin D testing to confirm levels stay within the 40–80 ng/mL optimal range. Toxicity (above 150 ng/mL) causes hypercalcemia with symptoms including nausea, weakness, and kidney strain. Annual bloodwork is appropriate for long-term users.

Vitamin D3 in chewable tablet form is well tolerated and rarely causes digestive issues at recommended doses. Taking with a fat-containing meal significantly improves absorption and minimizes the rare stomach discomfort some users report. The sugar-free sweetener used in the chocolate flavoring is safe but may cause mild laxative effects in very sensitive individuals at high intakes.

Pairs well with vitamin K2 (MK-7), magnesium (which activates vitamin D conversion), and calcium. Avoid combining with other high-dose fat-soluble vitamins (A, E, K) without professional guidance, as competing absorption pathways can create imbalances. Do not stack with other vitamin D supplements or cod liver oil without accounting for total IU intake.

Chew one tablet daily with a fat-containing meal to optimize absorption. Get baseline and periodic 25-OH vitamin D blood tests to ensure serum levels remain in the therapeutic range (40–80 ng/mL). At 5,000 IU daily, healthcare supervision is advisable, particularly for individuals with kidney disease or granulomatous conditions (sarcoidosis, tuberculosis) that can cause D3 hypersensitivity.

Serum vitamin D levels begin rising within 1–2 weeks of supplementation. Bone health improvements require 3–6 months of consistent use alongside adequate calcium intake. Immune support and mood benefits from D3 correction of deficiency are typically noticeable within 4–8 weeks. Benefits appear faster in severely deficient individuals starting with undetectable serum levels.