Integrative Therapeutics Buffered Vitamin C - Antioxidant Support Supplement for Healthy Skin & Connective Tissues* - Vegan & Gluten-Free - 60 Capsules (60 Servings)
$0.25/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
1000mg vitamin C (buffered) per capsule; 1 capsule daily of Buffered Vitamin C 1000mg per capsule per capsule from Integrative Therapeutics. Best for adults needing high-dose 1000mg vitamin C with…
Why we recommend this
Buffered Vitamin C earns 4.8 stars across 2,146 reviews — one of the highest-rated IT products in this batch. The buffered format meaningfully expands access to therapeutic-dose vitamin C for acid-sensitive users who cannot tolerate plain ascorbic acid.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
The buffering salt(s) are not fully disclosed in the Amazon listing, which matters for users monitoring sodium or calcium intake from supplements. Those needing doses above 1000mg will require multiple capsules.
Dose & form
- Serving
- 1000mg vitamin C (buffered) per capsule; 1 capsule daily
- Form
- Capsule
- Clinical range
- 500-1000mg daily
- Dose adequacy
- Therapeutic
- Supply
- 60 servings · $0.25/serving
- UPC
- 871791003354
Who it's best for
Adults needing high-dose 1000mg vitamin C with reduced acidity — ideal for acid-sensitive stomachs that cannot tolerate standard ascorbic acid
Who should skip it
Those seeking lower-dose vitamin C — each capsule delivers the full 1000mg
Pros
- 1000mg vitamin C per capsule — full therapeutic dose in one serving
- Buffered form — gentler on acid-sensitive stomachs than plain ascorbic acid
- 2,146 reviews at 4.8 stars — one of the highest ratings in this batch
- Vegan, gluten-free, soy-free with no artificial additives
Cons
- Single 1000mg dose cannot be halved without splitting capsules
- Buffering agents not fully disclosed in Amazon listing
- $15.25 for 60 capsules — competitive but check per-gram cost vs powder forms
What customers say
4.8★ across 2,146 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Buffered Vitamin C 1000mg per capsule?
What is the clinical dose for Buffered Vitamin C 1000mg per capsule?
Clinical trials typically use 500-1000mg daily. IT Buffered Vitamin C 1000mg Capsules (60ct) delivers 1000mg vitamin C (buffered) per capsule; 1 capsule daily, which we classify as Therapeutic relative to that range.
How does IT Buffered Vitamin C 1000mg Capsules (60ct) compare to similar Capsule?
How does IT Buffered Vitamin C 1000mg Capsules (60ct) compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is IT Buffered Vitamin C 1000mg Capsules (60ct) third-party tested?
Is IT Buffered Vitamin C 1000mg Capsules (60ct) third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
High-dose vitamin C (1000mg+) can reduce the effectiveness of some anticoagulants and interact with certain chemotherapy drugs. It can also interfere with lab tests for glucose and occult blood. Consult your physician if on these medications or undergoing medical testing.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Buffered vitamin C at 1000mg/day is well tolerated long-term for most adults. The buffered form reduces GI acidity side effects compared to plain ascorbic acid. Very high doses (4000mg+/day) can increase oxalate and kidney stone risk — 1000mg/day is within the safe range.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
The buffered form is specifically designed to minimize GI discomfort associated with plain ascorbic acid. Users with acid reflux or sensitive stomachs report better tolerance than standard vitamin C. Taking with food further reduces any residual GI sensitivity.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Vitamin C enhances iron absorption — take together with iron supplements. It pairs well with vitamin E and zinc for comprehensive immune and antioxidant support. Space from B12 as high-dose vitamin C can reduce B12 absorption in some studies.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 1 capsule daily with food for optimal tolerance. If using for immune support during illness, some practitioners recommend 2000mg/day short-term — consult your healthcare provider before exceeding the labeled dose. Do not combine with large doses of other ascorbate-containing supplements.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Plasma vitamin C levels normalize within days of consistent supplementation in deficient individuals. Immune support during acute illness is most effective when started at onset. Skin and collagen support benefits are cumulative, typically assessed after 8-12 weeks of daily use.
Also consider
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