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IT Lipase Concentrate-HP (90ct / 45 Servings) — view 1 of 5
Integrative Therapeutics

Integrative Therapeutics Lipase Concentrate-HP - Enzyme Supplement for the Digestion of Fats - Nutrient Absorption & GI Tract Health Support* - Dairy-Free & Vegan - 90 Count (45 Servings)

4.4· 1,338 Amazon reviews
$25.25$23.99with Subscribe & Save

$0.28/serving

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Price verified Apr 22, 2026

Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use

Our verdict

2 capsules per serving; 45 servings per 90-count bottle of Lipase (microbial, high-potency concentrate) per capsule from Integrative Therapeutics. Best for adults needing targeted fat-digestion enzyme support — especially those…

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Why we recommend this

Lipase Concentrate-HP stands out with 1,338 reviews at 4.4 stars — the strongest social proof of any product in this batch. Practitioner-grade GMP manufacturing and pH-stability across GI environments make it a reliable choice for clinical fat-digestion protocols.

Check for interactions

Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.

Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.

What to watch out for

As a single-enzyme concentrate, this product does not address protein or carbohydrate digestion. Users needing broad digestive enzyme support should consider the Similase line instead.

Dose & form

Serving
2 capsules per serving; 45 servings per 90-count bottle
Form
Capsule
Clinical range
Lipase enzyme supplementation studied at various FIP/LU unit doses for fat malabsorption and GI support
Dose adequacy
Therapeutic
Supply
90 servings · $0.28/serving
UPC
871791002760

Who it's best for

Adults needing targeted fat-digestion enzyme support — especially those with fat malabsorption, pancreatic insufficiency, or difficulty digesting high-fat meals

Who should skip it

Those seeking a broad multi-enzyme formula — this product is specialized for lipid digestion only

Pros

  • pH-stable formula — active in both acid and alkaline GI environments
  • 1,338 reviews at 4.4 stars — best-reviewed digestive product in this batch
  • Vegan and dairy-free — sourced from microbial (non-animal) enzymes
  • High-potency concentrate format for clinically meaningful fat digestion support

Cons

  • Two-capsule serving size — not a single-dose convenience option
  • Specialized for fat digestion only — not a complete digestive enzyme blend
  • $25.25 for 45 servings at the 2-capsule dose

What customers say

4.4★ across 1,338 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.

Frequently Asked Questions

What is the clinical dose for Lipase (microbial, high-potency concentrate)?

Clinical trials typically use Lipase enzyme supplementation studied at various FIP/LU unit doses for fat malabsorption and GI support. IT Lipase Concentrate-HP (90ct / 45 Servings) delivers 2 capsules per serving; 45 servings per 90-count bottle, which we classify as Therapeutic relative to that range.

How does IT Lipase Concentrate-HP (90ct / 45 Servings) compare to similar Capsule?

See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.

Is IT Lipase Concentrate-HP (90ct / 45 Servings) third-party tested?

Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.

Does this work with Amazon Subscribe & Save?

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Are there any potential interactions with medications?

Digestive enzyme supplements have minimal drug interaction potential at supplemental doses. Those with pancreatitis or on pancreatic enzyme replacement therapy (PERT) should consult their gastroenterologist before adding lipase supplements. No significant medication interactions are documented.

Are there any side effects from long-term use?

Lipase enzyme supplements are generally well tolerated with long-term use. Rare users report mild GI symptoms (bloating, cramping) during initial use. pH-stable microbial lipase is considered a safe supplement category. Adjust dose with practitioner guidance if GI symptoms occur.

Does it cause any digestive issues or side effects?

Designed to support rather than disrupt digestion — most users report improved fat digestion comfort. A small subset may experience loose stools or cramping as fat absorption normalizes. Take with meals as directed to minimize GI adjustment symptoms.

Can it be taken with other supplements or vitamins?

Compatible with fat-soluble vitamins (A, D, E, K) and omega-3 fatty acids — lipase supplementation can improve their absorption. Pairs naturally with other digestive enzymes (protease, amylase) for comprehensive digestive support. No adverse supplement interactions documented.

Are there any specific instructions for taking it safely?

Take 2 capsules with meals containing fat, as directed. Do not take on an empty stomach. For clinical fat malabsorption conditions, follow a practitioner's specific dosing protocol. Store away from moisture and heat to preserve enzyme activity.

How long until benefits are typically experienced?

Digestive enzyme benefits are typically meal-specific and immediate — taking lipase with a fat-containing meal can improve fat digestion comfort within 1-2 hours. Consistent use over 2-4 weeks allows assessment of cumulative improvement in fat absorption and nutrient status.

Also consider

As an Amazon Associate, we earn from qualifying purchases. Some links below are affiliate links — this doesn't affect our editorial independence or product ratings. How we evaluate products

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer