Integrative Therapeutics Riboflavin - B2 Vitamin Supplement for Cellular Energy Support* - Supports Vitality & Red Blood Cell Production* - Gluten-Free & Dairy-Free - 30 Count (30 Servings)

Clinical trials typically use Varies by formula; active B-complex with coenzyme forms recommended. Integrative Therapeutics Riboflavin B2 Vitamin delivers Riboflavin (B2) per tablet (30 tablets, 30 servings at 1 tablet/day); product weight listed as 400 mg per tablet, which we classify as Blend relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Tablet vs alternatives), dose adequacy, and third-party testing.

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High-dose riboflavin (400 mg) may enhance the activity of tricyclic antidepressants, some chemotherapy agents (doxorubicin), and phenothiazine medications, as riboflavin is involved in their metabolic pathways. Riboflavin absorption can be reduced by certain antibiotics (tetracyclines) and probenecid. Consult your prescriber if you are on any of these medications before starting 400 mg riboflavin.

Riboflavin is water-soluble with no established upper tolerable intake level — excess is excreted in urine, making toxicity extremely unlikely even at 400 mg/day. Long-term use at clinical migraine-prevention doses (400 mg for 3+ months) has been studied with no significant adverse effects. The distinctive bright yellow urine is a normal indicator of riboflavin excretion, not a sign of toxicity.

Riboflavin is generally very well tolerated with minimal GI side effects even at high doses. Some users report mild nausea if taken on an empty stomach, which is easily avoided by taking with food. The primary 'side effect' users notice is the bright yellow-orange coloration of urine, which is harmless and expected at 400 mg doses.

Riboflavin combines well with magnesium and Coenzyme Q10 in migraine prevention protocols — this three-way combination has clinical evidence supporting reduced migraine frequency. B2 also supports the activation of B6 and folate, making it complementary within a B-complex stack. No significant competitive absorption conflicts with common minerals.

Take 1 tablet daily with food unless otherwise directed by a healthcare professional. The 400 mg dose is a clinical dose — use under practitioner guidance if intended for migraine prevention. Riboflavin causes bright yellow urine at this dose, which is normal and harmless. Store in a cool, dry place away from light.

For migraine prevention, clinical trials using 400 mg riboflavin daily demonstrated statistically significant reductions in migraine frequency after 3 months of consistent use. General energy and vitality support effects may be noticed earlier — within 4–8 weeks for those with riboflavin deficiency. The cellular cofactor benefits are cumulative with sustained daily use.