Integrative Therapeutics Similase - Digestive Enzyme Supplement for Adults - Supports Digestion and Assimilation of Nutrients* - Dairy-Free & Vegan - 90 Count (45 Servings)

Clinical trials typically use Digestive enzyme dosing is measured in enzyme activity units (HUT, DU, FCC); activity levels not disclosed in listing. IT Similase Digestive Enzymes delivers 2 capsules per serving (90 capsules, 45 servings), which we classify as Blend relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.

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Digestive enzymes are generally considered low-interaction supplements. High-dose proteases may theoretically affect absorption of some oral medications if taken simultaneously — taking medications 30+ minutes before meals (and enzymes) is prudent. Those on blood thinners should note that high-dose protease enzymes have mild fibrinolytic properties at very high amounts.

Microbial digestive enzymes at supplemental doses are well tolerated long-term. A theoretical concern with prolonged use is reduced endogenous enzyme production (the body becoming reliant on supplemental enzymes), though this is not well substantiated in clinical literature. Periodic breaks from enzyme supplementation are sometimes recommended by practitioners.

Some users experience mild bloating, gas, or altered stool consistency in the first few days as enzyme activity changes gut transit. This typically resolves within 1–2 weeks. The 4.6-star rating from 904 reviewers reflects generally excellent tolerability. Starting with 1 capsule per meal reduces adaptation symptoms.

Digestive enzymes pair well with probiotics (different mechanisms, complementary effects), magnesium (muscle and GI motility support), and multivitamins (enzymes improve vitamin absorption). No meaningful interactions with most supplements. Some practitioners combine enzymes with HCl supplementation for comprehensive digestive support.

Take 1–2 capsules with each meal, or as directed by a healthcare professional. Enzymes should be taken at the start of a meal to be active while food is in the stomach and upper intestine. Do not take on an empty stomach for digestive enzyme purposes (though some systemic enzyme protocols do use between-meal dosing).

Digestive enzyme benefits are typically experienced at or shortly after the first meal they're taken with — reduced bloating, gas, and fullness often improve within the first 1–3 days of use. Users who don't notice immediate effects may have adequate endogenous enzyme production. Full benefit assessment takes 1–2 weeks of consistent use with meals.