Integrative Therapeutics Rhizinate, Sugarless, 100-Count

Clinical trials typically use DGL clinical studies use 380-760mg deglycyrrhizinated licorice extract before meals; tablet mg not disclosed in listing. IT Rhizinate Sugarless DGL Chewable delivers 2-3 chewable tablets per serving (100 tablets, approximately 33 servings), which we classify as Full relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Chewable vs alternatives), dose adequacy, and third-party testing.

Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

DGL (deglycyrrhizinated licorice) has a significantly reduced drug interaction profile compared to whole licorice. Minor interactions remain possible with antihypertensive and diuretic medications at very high doses. This product contains less than 1% glycyrrhizin which is the clinical standard for the DGL category. Consult your prescriber if on cardiovascular medications.

DGL is well tolerated long-term in clinical use. At less than 1% glycyrrhizin, long-term blood pressure effects are not a clinical concern at standard doses. The 642-review base at 4.6 stars includes long-term users without reported significant adverse effects.

DGL is specifically chosen for its lack of GI irritation unlike whole licorice. The chewable format allows mucosal contact before swallowing maximizing the demulcent effect. Mild licorice taste is inherent to the product. No GI side effects are expected at the standard 2-3 tablet dose.

DGL combines well with slippery elm, marshmallow root, and aloe vera for comprehensive GI mucosal support. Can be paired with digestive enzymes taken at the start of the meal while DGL is taken before. Compatible with probiotics and magnesium. No meaningful interactions with common supplements.

Chew 2-3 tablets 20 minutes before meals for maximum GI soothing benefit - the active DGL compounds need mucosal contact time before food enters. Can also be taken between meals for ongoing GI comfort support. Chew thoroughly before swallowing. Sugarless - appropriate for diabetic individuals.

DGL soothing effects on the GI mucosa are typically noticed within the first few days of use - reduced GI discomfort, less burning, and improved mucosal comfort are often reported quickly. Full mucosa-protective effects build over 2-4 weeks of consistent pre-meal use.