Integrative Therapeutics Similase Lipo - Digestion Supplement for Daily Enzyme Support* - Gastrointestinal Health & Gut Support Supplement - Dairy-Free & Vegan - 90 Capsules (45 Servings)
$0.37/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
2 capsules per serving; 45 servings per 90-count bottle of Multi-enzyme blend with enhanced lipase activity per capsule from Integrative Therapeutics. Best for adults who need fat-focused digestive enzyme support…
Why we recommend this
Similase Lipo fills the niche between a pure lipase concentrate and a general enzyme blend — ideal for patients whose primary digestive challenge is fat and fat-soluble nutrient assimilation. GMP certification and vegan sourcing add clinical credibility.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
Limited review count (133) makes it harder to assess real-world effectiveness broadly. The specialized lipid focus means it may not fully address protein or carbohydrate digestion needs in users with broader enzyme deficiencies.
Dose & form
- Serving
- 2 capsules per serving; 45 servings per 90-count bottle
- Form
- Capsule
- Clinical range
- Broad-spectrum digestive enzyme blends studied for GI support; enhanced lipase activity for fat-soluble nutrient assimilation
- Dose adequacy
- Blend
- Supply
- 90 servings · $0.37/serving
- UPC
- 871791001541
Who it's best for
Adults who need fat-focused digestive enzyme support with broader enzyme coverage than a standalone lipase product
Who should skip it
Those seeking a general all-in-one digestive enzyme — Similase Lipo is specifically weighted toward lipid digestion
Pros
- Range of digestive enzymes with additional lipase activity for fat digestion
- Supports fat-soluble nutrient absorption alongside general digestion
- Vegan and dairy-free formula — suitable for plant-based diets
- Practitioner-trusted IT brand with GMP manufacturing since 1979
Cons
- 133 reviews — modest social proof compared to other IT enzyme products
- Two-capsule serving size reduces convenience
- $33.50 for 45 servings is a premium price point
What customers say
4.6★ across 133 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Multi-enzyme blend with enhanced lipase activity?
What is the clinical dose for Multi-enzyme blend with enhanced lipase activity?
Clinical trials typically use Broad-spectrum digestive enzyme blends studied for GI support; enhanced lipase activity for fat-soluble nutrient assimilation. IT Similase Lipo Digestive Enzymes (90ct) delivers 2 capsules per serving; 45 servings per 90-count bottle, which we classify as Blend relative to that range.
How does IT Similase Lipo Digestive Enzymes (90ct) compare to similar Capsule?
How does IT Similase Lipo Digestive Enzymes (90ct) compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is IT Similase Lipo Digestive Enzymes (90ct) third-party tested?
Is IT Similase Lipo Digestive Enzymes (90ct) third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Broad-spectrum digestive enzymes have minimal drug interaction potential at supplemental doses. Those on pancreatic enzyme replacement therapy (PERT) for pancreatic insufficiency should consult their gastroenterologist before adding. No significant medication interactions are documented for microbial enzyme blends.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Digestive enzyme supplements including Similase Lipo are generally well tolerated long-term. Initial use may produce mild GI adjustment (bloating, loose stools) as fat digestion normalizes. These typically resolve within 1-2 weeks. No safety concerns with long-term enzyme supplementation.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Similase Lipo is designed to improve rather than disrupt digestion. As fat absorption normalizes, some users may experience stool changes. Taking 2 capsules with fat-containing meals as directed minimizes GI adjustment symptoms.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Pairs well with fat-soluble vitamins (A, D, E, K) and omega-3 fatty acids — improved lipase activity can enhance their absorption. Compatible with probiotics and other GI support supplements. No known adverse supplement-supplement interactions.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 2 capsules with each fat-containing meal. Do not take on an empty stomach. Enzyme activity requires food substrate present in the digestive tract. Store away from heat and moisture to preserve enzyme potency.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Digestive enzyme benefits are immediate — lipase activity begins with each meal dose. Sustained improvements in fat-soluble nutrient status (vitamin D levels, omega-3 integration) become measurable after 4-8 weeks of consistent use with meals.
