Integrative Therapeutics Similase Sensitive Stomach - Support for Sensitive Stomachs* - Dairy-Free & Vegan - 180 Capsules (90 Servings)
$0.28/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
2 capsules per serving; 90 servings per 180-count bottle of Microbial digestive enzymes + marshmallow, slippery elm, licorice root, gamma-oryzanol per capsule from Integrative Therapeutics. Best for adults with sensitive…
Why we recommend this
Similase Sensitive Stomach is the only IT digestive enzyme product pairing enzymes with mucosal-soothing botanicals. For practitioners managing patients with gastritis, GERD, or IBS, this combination is clinically distinct. Vegan and dairy-free with 237 reviews at 4.6 stars.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
The blend of soothing herbs reduces the total enzyme activity per capsule compared to pure enzyme products. Users needing maximum enzyme potency should consider Lipase Concentrate-HP or Similase instead. Individual botanical doses are not fully disclosed.
Dose & form
- Serving
- 2 capsules per serving; 90 servings per 180-count bottle
- Form
- Capsule
- Clinical range
- Botanical-enzyme blends for sensitive GI tract; each botanical component (slippery elm, licorice, marshmallow) has traditional use evidence for GI soothing
- Dose adequacy
- Blend
- Supply
- 180 servings · $0.28/serving
- UPC
- 871791001251
Who it's best for
Adults with sensitive stomachs needing digestive enzyme support combined with soothing botanicals like marshmallow, slippery elm, licorice, and gamma-oryzanol
Who should skip it
Those seeking a high-potency enzyme-only formula — this blends soothing herbs with enzymes rather than maximizing enzyme activity
Pros
- Combines enzymes with demulcent herbs for both digestion and GI soothing
- 180 capsules / 90 servings — generous 3-month supply at twice-daily dosing
- 237 reviews at 4.6 stars — strong satisfaction for a specialized formula
- Vegan and dairy-free with no artificial colors or flavors
Cons
- Proprietary blend — individual botanical doses not fully disclosed
- Two-capsule serving reduces convenience vs. single-capsule options
- $50.00 for 90 servings is a premium price point
What customers say
4.6★ across 237 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Microbial digestive enzymes + marshmallow, slippery elm, licorice root, gamma-oryzanol?
What is the clinical dose for Microbial digestive enzymes + marshmallow, slippery elm, licorice root, gamma-oryzanol?
Clinical trials typically use Botanical-enzyme blends for sensitive GI tract; each botanical component (slippery elm, licorice, marshmallow) has traditional use evidence for GI soothing. IT Similase Sensitive Stomach (180ct / 90 Servings) delivers 2 capsules per serving; 90 servings per 180-count bottle, which we classify as Blend relative to that range.
How does IT Similase Sensitive Stomach (180ct / 90 Servings) compare to similar Capsule?
How does IT Similase Sensitive Stomach (180ct / 90 Servings) compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is IT Similase Sensitive Stomach (180ct / 90 Servings) third-party tested?
Is IT Similase Sensitive Stomach (180ct / 90 Servings) third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Licorice root extract may interact with corticosteroids, antihypertensive medications, and potassium-depleting diuretics. Deglycyrrhizinated licorice (DGL), the likely form used, has a better safety profile. Consult your physician if on any of these medication classes. Enzymes themselves have minimal drug interactions.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
The botanical-enzyme combination is generally well tolerated. Licorice root at higher doses over extended periods can affect blood pressure and potassium — DGL form minimizes this risk. Slippery elm and marshmallow are safe traditional demulcents. Periodic review with a practitioner is advisable.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Designed to soothe rather than irritate sensitive stomachs. The demulcent herbs (marshmallow, slippery elm) coat the GI mucosa to reduce irritation. Most users with sensitive stomachs report improved comfort. Rare individuals may have sensitivity to one of the botanical components.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Compatible with most supplements. The slippery elm and marshmallow mucilage may slow absorption of some medications if taken simultaneously — space medications 1-2 hours from this supplement as a precaution. Pairs well with probiotics for comprehensive GI support.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 2 capsules with each meal as directed. Take medications at least 1-2 hours apart from slippery elm and marshmallow-containing supplements. Suitable for daily long-term use as directed. Not formulated for children without practitioner guidance.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Digestive enzyme benefits are meal-specific and immediate. GI soothing from demulcent herbs may be noticed within the first few days of consistent use. Cumulative improvement in overall GI comfort with sensitive stomach typically observed over 2-4 weeks of daily supplementation.
