Integrative Therapeutics Similase Sensitive Stomach - Support for Sensitive Stomachs* - Dairy-Free & Vegan - 90 Capsules (45 Servings)
$0.29/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
2 capsules per serving (90 capsules, 45 servings) of Microbial digestive enzymes + Marshmallow + Slippery Elm + Licorice Root + Gamma-Oryzanol per capsule from Integrative Therapeutics. Best for adults…
Why we recommend this
Similase Sensitive Stomach fills a specific clinical niche - individuals who need enzyme support but have reactive or inflamed GI tracts that make standard enzyme formulas uncomfortable. The soothing botanical additions are clinically informed and reflect Integrative Therapeutics integrative approach.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
The combination of enzymes and soothing botanicals is clinically thoughtful but may be redundant for some users. The licorice root component requires caution in hypertensive individuals, though the formula typically uses a low-glycyrrhizin form to minimize blood pressure effects.
Dose & form
- Serving
- 2 capsules per serving (90 capsules, 45 servings)
- Form
- Capsule
- Clinical range
- Enzyme activity varies by type; soothing botanicals typically 250-500mg/day in clinical use
- Dose adequacy
- Blend
- Supply
- 90 servings · $0.29/serving
- UPC
- 871791001268
Who it's best for
Adults with sensitive stomachs who need digestive enzyme support combined with soothing botanicals (marshmallow, slippery elm, licorice root, gamma-oryzanol)
Who should skip it
Those needing standard-spectrum enzyme support without botanical GI-soothing ingredients - the original Similase is more appropriate for general enzyme needs
Pros
- Unique combination of microbial enzymes with GI-soothing demulcent herbs for a two-pronged sensitive stomach approach
- 331 reviews at 4.6 stars for a specialized sensitive stomach formula
- Slippery elm and marshmallow root are traditionally recognized demulcent herbs for GI tract comfort
- Vegan, dairy-free, and free of artificial additives
Cons
- Licorice root should be used cautiously in those with high blood pressure or on blood pressure medications
- Only 45 servings per bottle - repurchase every 45 days for once-daily users
- The botanical GI-soothing focus may not suit users who need pure high-activity enzyme supplementation
What customers say
4.6★ across 331 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Microbial digestive enzymes + Marshmallow + Slippery Elm + Licorice Root + Gamma-Oryzanol?
What is the clinical dose for Microbial digestive enzymes + Marshmallow + Slippery Elm + Licorice Root + Gamma-Oryzanol?
Clinical trials typically use Enzyme activity varies by type; soothing botanicals typically 250-500mg/day in clinical use. IT Similase Sensitive Stomach (90ct) delivers 2 capsules per serving (90 capsules, 45 servings), which we classify as Blend relative to that range.
How does IT Similase Sensitive Stomach (90ct) compare to similar Capsule?
How does IT Similase Sensitive Stomach (90ct) compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is IT Similase Sensitive Stomach (90ct) third-party tested?
Is IT Similase Sensitive Stomach (90ct) third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
The licorice root component can interact with blood pressure medications, diuretics, and corticosteroids. Digestive enzymes have minimal drug interactions. Consult your prescriber if on antihypertensives or steroids. Marshmallow and slippery elm slow GI transit slightly which may affect absorption timing of some medications.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Microbial enzymes and demulcent herbs are well tolerated long-term. Licorice root at high doses long-term can raise blood pressure, but the low-glycyrrhizin form used in these formulas minimizes this risk. The 331-review base at 4.6 stars includes long-term users without significant reported concerns.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
This formula is specifically designed to reduce digestive side effects - the soothing botanicals create a protective mucosal coating that reduces GI irritation. Most users report improved GI comfort compared to standard enzyme products. Mild adaptation (gas/bloating) is still possible in the first 1-2 weeks.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Works well alongside probiotics for combined microbiome and enzyme support. Can be paired with Betaine HCl for more complete upper GI support under practitioner guidance. Avoid stacking with other licorice root products to manage total glycyrrhizin intake.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 2 capsules with meals, or as directed by a healthcare provider. The soothing botanical ingredients make it appropriate to take at the start of meals alongside food. Adequate water with each dose is recommended.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Enzyme-mediated digestion improvements are typically noticeable within the first 1-3 meals. The GI-soothing botanical effects build over 1-2 weeks. Users with chronic GI sensitivity often report significant comfort improvements within the first week of consistent use.
