Integrative Therapeutics Liquid Calcium Magnesium 2:1 - Calcium Supplement for Bone Support* - Delicious, Liquid Formula - Does Not Contain Sugar, Gluten or Dairy - Orange Vanilla, 16 oz (32 Servings)
$1.61/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
1 tablespoon (15 mL) once daily with food (32 servings per 16 oz bottle) of Calcium Citrate + Magnesium Citrate + Vitamin D (400 IU) per liquid from Integrative Therapeutics…
Why we recommend this
Integrative Therapeutics formulated this liquid calcium-magnesium supplement for patients who cannot tolerate standard tablets, using the more absorbable citrate form with vitamin D co-inclusion — a thoughtful clinical design that reflects the brand's 45+ year practitioner heritage. The 2:1 Cal-Mag ratio and citrate delivery represent evidence-informed mineral supplementation rather than generic calcium formulation.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
The 400 IU vitamin D per serving addresses baseline cofactor support but is insufficient for individuals with vitamin D deficiency (typically requiring 2000–5000 IU daily under clinical guidance). The liquid format, while beneficial for absorption and swallowing ease, requires careful handling, refrigeration after opening, and limits portability compared to capsule forms.
Dose & form
- Serving
- 1 tablespoon (15 mL) once daily with food (32 servings per 16 oz bottle)
- Form
- Liquid
- Clinical range
- Calcium: 500–1200mg/day for adults; Magnesium: 200–400mg/day; 400 IU vitamin D is a baseline support dose (clinical therapeutic range 1000–5000 IU)
- Dose adequacy
- Citrate form supports superior absorption vs. calcium carbonate; 400 IU vitamin D per serving supports calcium metabolism at a clinically meaningful level
- Supply
- 16 servings · $1.61/serving
- UPC
- 871791100206
Who it's best for
Adults who prefer a liquid mineral supplement or have difficulty swallowing capsules, seeking combined calcium and magnesium in absorbable citrate form with vitamin D
Who should skip it
Those seeking standalone calcium or standalone magnesium supplements, or those requiring higher doses of either mineral for clinical deficiency
Pros
- Liquid citrate form delivers better absorption than calcium carbonate tablets, particularly for older adults with reduced stomach acid
- 2:1 calcium-to-magnesium ratio reflects clinically recognized balance for bone and muscle health support
- Includes 400 IU vitamin D per serving to enhance calcium absorption — addressing the key cofactor deficiency
- Sugar-free orange vanilla flavor improves daily compliance for those who struggle with unflavored liquid minerals
Cons
- 32 servings per 16 oz bottle at $25.75 — moderate cost for a combination mineral product
- 400 IU vitamin D is a maintenance dose, not a therapeutic dose for deficiency — those with low 25(OH)D may need additional vitamin D
- Liquid format requires refrigeration after opening and has a shorter shelf life than capsules
What customers say
4.6★ across 947 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Calcium Citrate + Magnesium Citrate + Vitamin D (400 IU)?
What is the clinical dose for Calcium Citrate + Magnesium Citrate + Vitamin D (400 IU)?
Clinical trials typically use Calcium: 500–1200mg/day for adults; Magnesium: 200–400mg/day; 400 IU vitamin D is a baseline support dose (clinical therapeutic range 1000–5000 IU). Integrative Therapeutics Liquid Calcium Magnesium delivers 1 tablespoon (15 mL) once daily with food (32 servings per 16 oz bottle), which we classify as Citrate form supports superior absorption vs. calcium carbonate; 400 IU vitamin D per serving supports calcium metabolism at a clinically meaningful level relative to that range.
How does Integrative Therapeutics Liquid Calcium Magnesium compare to similar Liquid?
How does Integrative Therapeutics Liquid Calcium Magnesium compare to similar Liquid?
See the "Also consider" section below for two alternatives. Choose based on form preference (Liquid vs alternatives), dose adequacy, and third-party testing.
Is Integrative Therapeutics Liquid Calcium Magnesium third-party tested?
Is Integrative Therapeutics Liquid Calcium Magnesium third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Calcium can reduce the absorption of thyroid medications (levothyroxine), certain antibiotics (quinolones, tetracyclines), and bisphosphonates — separate calcium doses by at least 2 hours from these medications. Magnesium may potentiate the effects of blood pressure medications and muscle relaxants. Vitamin D can interact with thiazide diuretics by increasing calcium absorption to levels requiring monitoring.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Long-term calcium supplementation above 1200mg/day has been associated in some studies with increased cardiovascular risk — use the lowest effective dose. Magnesium at dietary-range doses is well tolerated long-term. The vitamin D included (400 IU) is far below the tolerable upper intake level (4000 IU) and presents no long-term toxicity concern at this dose.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Calcium citrate is significantly less likely to cause constipation and bloating than calcium carbonate, making this liquid citrate formula one of the better-tolerated calcium supplement formats. Magnesium at higher doses can cause loose stools in sensitive individuals — the 2:1 ratio keeps magnesium at moderate levels. Taking with food further reduces GI sensitivity.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
This formula already includes vitamin D, so factor that into total daily vitamin D intake before adding another D supplement. Calcium competes with iron and zinc for absorption — take those minerals at a different time of day. Magnesium pairs well with vitamin B6 for enhanced cellular uptake, and the combination supports both bone and muscle function.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 1 tablespoon (15 mL) once daily with food. Shake well before each use as liquid mineral suspensions can settle. Refrigerate after opening and use within the stated shelf life. Do not exceed the recommended dose without healthcare provider guidance, particularly regarding cumulative calcium intake from food and other supplements.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Bone density changes from calcium and vitamin D supplementation require 6–12 months to be measurable via DEXA scan — this is a long-term support supplement, not an acute intervention. Muscle function support from magnesium may be noticeable within 2–4 weeks of consistent use in depleted individuals. Daily consistency is essential for cumulative bone health benefits.
