Integrative Therapeutics Lipotropic Complex - Liver Support Supplement for Adults* - Includes Milk Thistle & Vitamin B6 and B12 - Gluten-Free & Dairy-Free - 90 Count (45 Servings)

Clinical trials typically use Milk thistle (silymarin): 140–400 mg/day for liver support; choline: 400–550 mg/day; methylcobalamin: 500–1,000 mcg/day. Integrative Therapeutics Lipotropic Complex delivers 2 capsules per serving (90 capsules per bottle, 45 servings), which we classify as The combination of methyl donors, silymarin, and biliary botanicals addresses liver support from multiple complementary pathways. Active B-vitamin forms (methylcobalamin, P5P) indicate superior bioavailability over synthetic forms. Exact per-ingredient doses should be confirmed on the product label. relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.

Yes — Third-Party Tested. Third-party testing verifies ingredient identity and label accuracy.

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Milk thistle (silymarin) can affect CYP450 liver enzymes and may alter the metabolism of certain medications including statins, certain antibiotics, and blood thinners — consult your doctor if you are on prescription medications processed by the liver. The methylcobalamin B12 and active B6 (P5P) forms are well tolerated alongside most medications. Bile-stimulating botanicals (dandelion, fringe tree) may affect medications that rely on bile absorption.

Silymarin has a strong long-term safety profile in clinical use, with studies up to 41 months showing no significant adverse effects. Choline and methionine at supplemental doses are well tolerated in healthy adults. The ox bile component is generally safe but may cause loose stools in some individuals, particularly at first introduction.

The combination of ox bile and biliary botanicals is designed to support digestion, but in some individuals — particularly those not accustomed to bile-stimulating supplements — it may initially cause looser stools or increased bowel frequency. Starting with 1 capsule per meal and gradually increasing to the full serving can help the digestive system adjust. Most users adapt within 1–2 weeks.

Lipotropic Complex covers B-vitamins (B6, B12, folate) and choline, so additional high-dose supplementation of these nutrients should be tallied to avoid exceeding tolerable upper intake levels. It stacks well with omega-3s for combined liver and lipid health support. Avoid combining with additional high-dose milk thistle supplements to prevent silymarin overdosing.

Take 2 capsules per serving with meals as directed to support bile function and reduce GI discomfort. Not suitable for vegans or vegetarians due to ox bile content. Consult your healthcare provider before use if you have gallbladder disease, bile duct obstruction, or are on medications metabolized by the liver.

Silymarin's hepatoprotective effects in clinical studies are measured over 4–12 weeks of consistent use. Improvements in liver enzyme markers (ALT, AST) in response to milk thistle supplementation have been observed as early as 4–8 weeks. Methyl-donor nutrients support ongoing detoxification pathways from the first dose, though functional liver improvements are cumulative.