Integrative Therapeutics Cortisol Manager Allergen Free - Adrenal Health Support Supplement for Healthy Stress Response* - Vegan, Non-Dairy & Gluten-Free - 30 Capsules (15 Servings)
$0.95/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
2 capsules per serving; 15 servings per 30-capsule bottle of Ashwagandha + L-Theanine + Phosphatidylserine per capsule from Integrative Therapeutics. Best for stress-prone adults and professionals who need evening cortisol…
Why we recommend this
Cortisol Manager Allergen Free earns its 1,951-review, 4.5-star standing by combining three well-researched cortisol-regulating ingredients into a single evening formula that serves the stress-sleep axis simultaneously. The verified top-9 allergen-free status expands access to users who typically cannot use standard supplement formulations.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
The 15-serving bottle is a significant supply limitation — users run out every two weeks at the recommended dose, increasing cost per month relative to competing 30-day supply products. Ashwagandha-sensitive individuals (thyroid conditions, autoimmune disease) cannot use this formula without physician guidance.
Dose & form
- Serving
- 2 capsules per serving; 15 servings per 30-capsule bottle
- Form
- Capsule
- Clinical range
- Ashwagandha: 300–600 mg/day KSM-66; L-theanine: 100–400 mg/day; Phosphatidylserine: 100–400 mg/day
- Dose adequacy
- Blend
- Supply
- 30 servings · $0.95/serving
Who it's best for
Stress-prone adults and professionals who need evening cortisol reduction and sleep quality improvement from a top-9 allergen-free clinical formula with ashwagandha and L-theanine
Who should skip it
Individuals with thyroid disorders (ashwagandha requires caution), those needing same-night immediate sedation, or those wanting a melatonin-based sleep supplement
Pros
- Clinically validated ashwagandha + L-theanine + phosphatidylserine cortisol-management stack in a single formula
- Manufacturer-verified free of all top-9 US food allergens — one of the broadest allergen-free claims in the category
- 1,951 Amazon reviews at 4.5 stars — highest review volume of the 5 ASINs, indicating broad user validation
- Vegan formula with no dairy, no gelatin, no animal-derived ingredients
Cons
- Only 15 servings per bottle (30 capsules at 2/day) — a 2-week supply requires repurchasing frequently
- Ashwagandha requires caution in thyroid disorders and pregnancy; limits eligible user population
- Exact per-ingredient milligrams require checking the label — multi-ingredient blends warrant dose transparency verification
What customers say
4.5★ across 1,951 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Ashwagandha + L-Theanine + Phosphatidylserine?
What is the clinical dose for Ashwagandha + L-Theanine + Phosphatidylserine?
Clinical trials typically use Ashwagandha: 300–600 mg/day KSM-66; L-theanine: 100–400 mg/day; Phosphatidylserine: 100–400 mg/day. Integrative Therapeutics Cortisol Manager Allergen Free delivers 2 capsules per serving; 15 servings per 30-capsule bottle, which we classify as Blend relative to that range.
How does Integrative Therapeutics Cortisol Manager Allergen Free compare to similar Capsule?
How does Integrative Therapeutics Cortisol Manager Allergen Free compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is Integrative Therapeutics Cortisol Manager Allergen Free third-party tested?
Is Integrative Therapeutics Cortisol Manager Allergen Free third-party tested?
Yes — GMP-manufactured; USA-bottled and tested; manufacturer-verified allergen-free (top 9 US allergens). Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Ashwagandha can potentiate sedative medications, thyroid hormone replacement, and immunosuppressants — consult your prescriber if you are on any of these. L-theanine has very limited drug interactions at supplemental doses but may enhance the sedative effect of anti-anxiety medications. Phosphatidylserine may mildly interact with blood thinners (anticoagulants) and anticholinergic drugs; discuss with your physician if you are on these medications.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Clinical trials on ashwagandha have run up to 12 weeks safely, with some protocols recommending an 8-12 week on, 2-4 week off cycling approach for long-term use. L-theanine has no established tolerance risk and is safe for sustained daily use. Phosphatidylserine at 100–300 mg/day has a clean long-term safety profile in both adult and elderly populations. Monitor thyroid function if using ashwagandha long-term with a pre-existing thyroid condition.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Ashwagandha can cause mild GI upset (nausea, loose stools) in sensitive individuals, particularly on an empty stomach. L-theanine and phosphatidylserine are both well tolerated with minimal GI effects. Starting with one capsule per serving (half dose) for the first week can help assess individual tolerance before advancing to the full 2-capsule serving.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Cortisol Manager pairs well with magnesium glycinate, vitamin B5 (pantothenic acid), and adaptogen-free vitamin complexes for a comprehensive adrenal support protocol. Avoid stacking with other ashwagandha or Rhodiola products to prevent adaptogen overload. It can safely be combined with a probiotic, omega-3, or vitamin D supplement without interaction concerns.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 2 capsules at bedtime or as directed by a healthcare provider — evening dosing aligns with the natural cortisol diurnal pattern where evening cortisol suppression supports sleep onset. Not recommended during pregnancy or breastfeeding without physician approval due to ashwagandha. Individuals with autoimmune thyroid conditions (Hashimoto's, Graves') should consult their physician before use.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
L-theanine's calming and sleep-onset effects can be noticed within the first 1–3 nights of use at adequate doses. Ashwagandha's cortisol-lowering and stress-resilience benefits build over 4–8 weeks of consistent daily use, consistent with KSM-66 and Sensoril clinical trial timelines. Phosphatidylserine's cognitive and HPA axis modulation effects are also cumulative, appearing over 3–6 weeks.
