
Sunergetic Premium Serrapeptase Enzyme Supplement - Helps Support Sinus Health - Powerful Serrapeptase Enzymes Formula - 40,000 SU Per Capsule - 90 Enteric Coated Serrapeptase Capsules
$0.21/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
40,000 SU serrapeptase per capsule; 90 servings per bottle of Serrapeptase 40,000 SU (enteric coated) per capsule (enteric coated) from Sunergetic. Best for users seeking high-potency serrapeptase with enteric coating…
Why we recommend this
40,000 SU per capsule is a strong clinical-range serrapeptase dose, and enteric coating is essential for this acid-sensitive enzyme to reach the intestine intact. 90-capsule bottle provides 3-month supply for consistent therapeutic dosing.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
Serrapeptase has mild blood-thinning effects and should not be combined with anticoagulant medications without physician oversight. Enzyme potency (SU) can vary between manufacturers — without published third-party COAs, actual SU delivery is not independently verified.
Dose & form
- Serving
- 40,000 SU serrapeptase per capsule; 90 servings per bottle
- Form
- Capsule (Enteric Coated)
- Clinical range
- 10,000-60,000 SU/day in clinical trials for sinus and inflammation endpoints
- Dose adequacy
- Therapeutic
- Supply
- 90 servings · $0.21/serving
- UPC
- 852207008668
Who it's best for
Users seeking high-potency serrapeptase with enteric coating for sinus, inflammation, and mucous support at a research-aligned potency
Who should skip it
Users on anticoagulant medications or needing alternative proteolytic enzymes like nattokinase or bromelain
Pros
- 40,000 SU per capsule is a high-potency therapeutic-range dose
- Enteric coating protects the heat-sensitive enzyme through stomach acid transit
- 864 reviews at 4.4 stars indicates solid consumer track record
- Non-GMO formulation
Cons
- Third-party testing not publicly disclosed — no published COAs on the brand site
- Serrapeptase potency cannot be independently verified without published COAs
- Can enhance bleeding risk with anticoagulants
What customers say
4.4★ across 864 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Serrapeptase 40,000 SU (enteric coated)?
What is the clinical dose for Serrapeptase 40,000 SU (enteric coated)?
Clinical trials typically use 10,000-60,000 SU/day in clinical trials for sinus and inflammation endpoints. Sunergetic Serrapeptase 40000 SU Enteric Coated delivers 40,000 SU serrapeptase per capsule; 90 servings per bottle, which we classify as Therapeutic relative to that range.
How does Sunergetic Serrapeptase 40000 SU Enteric Coated compare to similar Capsule (Enteric Coated)?
How does Sunergetic Serrapeptase 40000 SU Enteric Coated compare to similar Capsule (Enteric Coated)?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule (Enteric Coated) vs alternatives), dose adequacy, and third-party testing.
Is Sunergetic Serrapeptase 40000 SU Enteric Coated third-party tested?
Is Sunergetic Serrapeptase 40000 SU Enteric Coated third-party tested?
Yes — GMP manufactured; third-party testing not publicly disclosed. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Serrapeptase has anticoagulant activity — can enhance warfarin, aspirin, and other blood thinners. Consult your physician before combining. May interact with NSAIDs by potentiating anti-inflammatory effects. Discontinue at least 2 weeks before any scheduled surgery to prevent excessive bleeding.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Serrapeptase has favorable long-term safety profiles in clinical trials up to 12 months. Used pharmaceutically in Japan and Europe for decades. No known long-term organ toxicity at supplement doses. Monitor for bleeding signs (easy bruising, prolonged bleeding) with chronic use.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
Generally well tolerated when taken on empty stomach with water. Rare reports of mild stomach upset, nausea, or skin rash. Enteric coating minimizes gastric irritation. Take first thing in the morning or 2 hours between meals for optimal enzyme activity.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Pairs well with nattokinase and other proteolytic enzymes for systemic enzyme therapy. Avoid combining with high-dose omega-3, vitamin E, or other blood-thinning supplements to prevent excessive cumulative anticoagulant effect. Consult physician before stacking.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 1 capsule daily on an empty stomach (at least 30 minutes before or 2 hours after meals) for optimal systemic enzyme activity. Drink plenty of water. Do not chew or open the enteric-coated capsule. Discontinue 2 weeks before surgery. Consult physician if on anticoagulants.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Sinus and inflammatory benefits typically emerge within 2-4 weeks of daily use. Chronic inflammation and fibrin clearance benefits are cumulative over 8-12 weeks. Individual response varies significantly based on condition severity.

