This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
A systematic review of 24 clinical trials found that resveratrol supplementation (150-500mg/day) significantly reduced systolic blood pressure by 3.5 mmHg and improved flow-mediated dilation by 1.5%, with the strongest effects in participants with existing metabolic dysfunction.
| Study | Participants | Finding | Quality |
|---|---|---|---|
Effects of resveratrol on blood pressure: a systematic review and meta-analysis Liu Y, Ma W, Zhang P, He S, Huang D — Nutrition, Metabolism and Cardiovascular Diseases (2015) | 681 | Resveratrol significantly reduced systolic blood pressure in a dose-dependent manner at doses ≥150mg/day | High |
For adults with cardiovascular risk factors, 150-500mg/day of trans-resveratrol may provide modest blood pressure and endothelial function benefits. Choose formulations with enhanced bioavailability (micronized or liposomal) and combine with other heart-healthy practices for meaningful impact.
A comprehensive systematic review evaluating the effects of resveratrol supplementation on cardiovascular risk markers including blood pressure, lipid profiles, and inflammatory biomarkers across human clinical trials.
Clinical evidence shows modest cardiovascular benefits. Resveratrol can reduce systolic blood pressure by about 3.5 mmHg and improve blood vessel function. However, effects are most meaningful in people with existing cardiovascular risk factors, not healthy individuals.
Clinical trials showing cardiovascular benefits used 150-500mg/day of trans-resveratrol. Higher doses (1,000mg+) have not shown proportionally greater benefits and may cause GI side effects. Start at 150-250mg/day with a bioavailability-enhanced formulation.
No. Red wine contains only 1-2mg of resveratrol per glass — far below the 150-500mg/day used in clinical trials. You would need to drink 75-250 glasses daily to match supplement doses, which would obviously cause far more harm than benefit.
Look for trans-resveratrol, which is the bioactive form. Standard resveratrol has low oral bioavailability (~20%), so micronized, liposomal, or formulations with piperine for enhanced absorption are preferred. Avoid cis-resveratrol, which is less active.