General Dosage
300-600mg alpha lipoic acid daily (150-300mg if using R-ALA)
Maximum dose: 1800mg/day racemic ALA (used in clinical trials for diabetic neuropathy)
Alpha Lipoic Acid (Liver Support) Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 300-600mg alpha lipoic acid daily (150-300mg if using R-ALA)
Timing: Take on an empty stomach 30 minutes before meals for best absorption
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General liver antioxidant support | 300mg ALA or 150mg R-ALA daily | Moderate |
| NAFLD/fatty liver | 600-1200mg ALA daily | Moderate |
| Heavy metal chelation support | 300-600mg ALA daily | Emerging |
| Insulin resistance (liver-related) | 600mg ALA daily | Strong |
Upper limit: 1800mg/day racemic ALA (used in clinical trials for diabetic neuropathy)
Timing & Absorption
Take on an empty stomach 30 minutes before meals for best absorption
Can be taken with or without food.
References
- Packer L, Witt EH, Tritschler HJ (1995). Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine. DOI PubMed
- Koh EH, Lee WJ, Lee SA, Kim EH, Cho EH, Jeong E, Kim DW, Kim MS, Park JY, Park KG, Lee HJ, Lee IK, Lim S, Jang HC, Lee KH, Lee KU (2011). Effects of alpha-lipoic acid on body weight in obese subjects. American Journal of Medicine. DOI PubMed
- Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K (1999). Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology and Medicine. DOI PubMed
- Patrick L (2002). Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Alternative Medicine Review. PubMed