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Andrographis Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • GI upset (nausea, vomiting, diarrhea) due to extreme bitterness — take with food to minimize
  • Headache and fatigue at higher doses
  • Allergic skin rash (rare)
  • Potential anti-fertility effects at very high doses — observed in animal studies; clinical significance uncertain

Drug & Supplement Interactions

  • Anticoagulants and antiplatelets — andrographolide has antiplatelet activity; may increase bleeding risk
  • Antihypertensive medications — andrographis may lower blood pressure; monitor for additive hypotension
  • Immunosuppressants — may counteract immunosuppressive therapy

Maximum Dose

Do not exceed: No established upper limit; doses up to 1200mg/day used in clinical trials without serious adverse effects

Full Andrographis Guide

References

  1. (). Andrographis paniculata (Chuanxinlian) for symptomatic relief of acute respiratory tract infections in adults and children. Cochrane Database of Systematic Reviews. DOI
  2. (). Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Medica. DOI