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AREDS2 Formula Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

Vitamin C 500 mg, vitamin E 400 IU, zinc 80 mg, copper 2 mg, lutein 10 mg, zeaxanthin 2 mg — typically 2 capsules daily

Maximum dose: Follow the standard AREDS2 dosage; zinc at 80 mg is already near the upper tolerable limit (40 mg UL, though 80 mg was well-tolerated in the trial)

Dosage Recommendations

General recommendation: Vitamin C 500 mg, vitamin E 400 IU, zinc 80 mg, copper 2 mg, lutein 10 mg, zeaxanthin 2 mg — typically 2 capsules daily

Timing: Divided into two doses daily (morning and evening) with meals • Take with food for best absorption.

Dosage by Condition

Intermediate AMD (both eyes)
Full AREDS2 formula dailyStrong
Advanced AMD in one eye
Full AREDS2 formula dailyStrong
Early AMD / prevention
Not proven beneficial — AREDS2 studied intermediate-to-advanced AMDModerate

Upper limit: Follow the standard AREDS2 dosage; zinc at 80 mg is already near the upper tolerable limit (40 mg UL, though 80 mg was well-tolerated in the trial)

Timing & Absorption

Divided into two doses daily (morning and evening) with meals

Best taken with food for optimal absorption.

References

  1. RCTAge-Related Eye Disease Study 2 Research Group (2013). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. DOI PubMed
  2. RCTChew EY, Clemons TE, Agrón E, et al. (2022). Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. JAMA Ophthalmology. DOI PubMed
  3. RCTAge-Related Eye Disease Study Research Group (2001). A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8. Archives of Ophthalmology. DOI PubMed