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AREDS2 Formula — Frequently Asked Questions

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Frequently Asked Questions

Who should take the AREDS2 formula?

AREDS2 is recommended for people diagnosed with intermediate AMD in one or both eyes, or advanced AMD in one eye. It is NOT proven to prevent AMD from starting or to help early-stage AMD. Ask your ophthalmologist to stage your AMD before starting. The formula is not recommended for people without AMD.

What changed from AREDS to AREDS2?

The main change was replacing beta-carotene (15 mg) with lutein (10 mg) and zeaxanthin (2 mg). Beta-carotene was linked to increased lung cancer risk in smokers. The AREDS2 10-year follow-up confirmed that lutein/zeaxanthin was actually more effective than beta-carotene for AMD prevention, making it the preferred formulation for all patients.

Can I take AREDS2 as a general eye vitamin?

AREDS2 was specifically designed and tested for intermediate-to-advanced AMD. For general eye health without AMD, the high zinc dose (80 mg) may be unnecessary and could cause side effects. A simpler lutein/zeaxanthin supplement (10 mg/2 mg) may be more appropriate for general macular support.

Full AREDS2 Formula Guide

References

  1. (). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. DOI
  2. (). Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. JAMA Ophthalmology. DOI
  3. (). A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8. Archives of Ophthalmology. DOI