General Dosage
325-650mg with each protein-containing meal
Maximum dose: Titrate to warm sensation in stomach, then reduce by one capsule; typically 1,950-3,250mg/meal maximum
Betaine HCl Dosage Guide
Evidence:Emerging
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Dosage Recommendations
General recommendation: 325-650mg with each protein-containing meal
Timing: Take with the first few bites of a protein-containing meal • Take with food for best absorption.
Dosage by Condition
Hypochlorhydria
325-650mg with meals, titrate up as neededEmerging
SIBO (adjunctive)
650mg with meals to increase gastric acid barrierPreliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Hypochlorhydria | 325-650mg with meals, titrate up as needed | Emerging |
| SIBO (adjunctive) | 650mg with meals to increase gastric acid barrier | Preliminary |
Upper limit: Titrate to warm sensation in stomach, then reduce by one capsule; typically 1,950-3,250mg/meal maximum
Timing & Absorption
Take with the first few bites of a protein-containing meal
Best taken with food for optimal absorption.
References
- RCTYago MR, Frymoyer AR, Smelick GS, et al. (2013). Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Molecular Pharmaceutics. DOI PubMed
- ReviewMartinsen TC, Bergh K, Waldum HL. (2005). Gastric juice: a barrier against infectious diseases. Basic & Clinical Pharmacology & Toxicology. DOI PubMed
- RCTOstojic SM, Niess B, Stojanovic M, Obrenovic M (2013). Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone.. The British journal of nutrition. DOI PubMed