General Dosage
325-650mg with each protein-containing meal
Maximum dose: Titrate to warm sensation in stomach, then reduce by one capsule; typically 1,950-3,250mg/meal maximum
Betaine HCl Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 325-650mg with each protein-containing meal
Timing: Take with the first few bites of a protein-containing meal • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Hypochlorhydria | 325-650mg with meals, titrate up as needed | Emerging |
| SIBO (adjunctive) | 650mg with meals to increase gastric acid barrier | Preliminary |
Upper limit: Titrate to warm sensation in stomach, then reduce by one capsule; typically 1,950-3,250mg/meal maximum
Timing & Absorption
Take with the first few bites of a protein-containing meal
Best taken with food for optimal absorption.
References
- Yago MR, Frymoyer AR, Smelick GS, et al. (2013). Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Molecular Pharmaceutics. DOI PubMed
- Martinsen TC, Bergh K, Waldum HL. (2005). Gastric juice: a barrier against infectious diseases. Basic & Clinical Pharmacology & Toxicology. DOI PubMed