Evidence Level
Emerging
Boron research is still emerging but promising. The foundational work by Nielsen et al. (USDA, 1987) established that boron deprivation in postmenopausal women increased urinary calcium loss and negatively affected mineral metabolism. Naghii et al. (2011) demonstrated short-term testosterone elevation with 10mg daily in a small (n=8) but well-designed study. The most robust clinical evidence comes from calcium fructoborate studies: Pietrzkowski et al. (2014, n=60) showed significant CRP reduction in a double-blind RCT. However, most boron studies are small, and larger confirmatory trials are needed.