General Dosage
350 mg daily (wheat-derived) or 40 mg daily (rice-derived)
Maximum dose: 350 mg/day for wheat-derived is the standard clinical dose; higher doses not studied
Ceramides (Phytoceramides) Dosage Guide
Evidence:Moderate
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Dosage Recommendations
General recommendation: 350 mg daily (wheat-derived) or 40 mg daily (rice-derived)
Timing: Take with a meal for optimal absorption of these lipid-based compounds • Take with food for best absorption.
Dosage by Condition
Dry skin and hydration
350 mg daily for 4-12 weeksModerate
Skin barrier repair
350 mg dailyModerate
Skin roughness
40 mg daily (rice-derived) for 6 weeksModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Dry skin and hydration | 350 mg daily for 4-12 weeks | Moderate |
| Skin barrier repair | 350 mg daily | Moderate |
| Skin roughness | 40 mg daily (rice-derived) for 6 weeks | Moderate |
Upper limit: 350 mg/day for wheat-derived is the standard clinical dose; higher doses not studied
Timing & Absorption
Take with a meal for optimal absorption of these lipid-based compounds
Best taken with food for optimal absorption.
References
- RCTGuillou S, Ghabri S, Jeantet C, et al. (2011). The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial. International Journal of Cosmetic Science. DOI PubMed
- Asai S, Miyachi H. (2003). Evaluation of skin moisturizing effect of oral intake of glucosylceramides derived from rice. Journal of Oleo Science.
- ReviewImokawa G. (2009). A possible mechanism underlying the ceramide deficiency in atopic dermatitis. Journal of Dermatological Science. DOI PubMed
- ReviewTessema EN, Gebre-Mariam T, Neubert RHH, Wohlrab J. (2017). Potential applications of phyto-derived ceramides in improving epidermal barrier function. Skin Pharmacology and Physiology. DOI PubMed