General Dosage
220-500mg standardized chamomile extract (1.2% apigenin) daily
Maximum dose: 1,500mg extract/day (the Mao 2016 study used up to 1,500mg daily without adverse effects)
Chamomile Dosage Guide
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Dosage Recommendations
General recommendation: 220-500mg standardized chamomile extract (1.2% apigenin) daily
Timing: For anxiety: divided doses morning and evening. For sleep: 30-60 minutes before bed.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Generalized anxiety disorder | 220-500mg standardized extract daily | Moderate |
| Sleep support | 200-400mg extract or 1-2 cups tea before bed | Moderate |
| Digestive comfort | 1-2 cups chamomile tea after meals | Emerging |
Upper limit: 1,500mg extract/day (the Mao 2016 study used up to 1,500mg daily without adverse effects)
Timing & Absorption
For anxiety: divided doses morning and evening. For sleep: 30-60 minutes before bed.
Can be taken with or without food.
References
- Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J (2009). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of Clinical Psychopharmacology. DOI PubMed
- Mao JJ, Xie SX, Keefe JR, Soeller I, Li QS, Amsterdam JD (2016). Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine. DOI PubMed
- Adib-Hajbaghery M, Mousavi SN (2017). The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complementary Therapies in Medicine. DOI PubMed
- Amsterdam JD, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB (2012). Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. Alternative Therapies in Health and Medicine. PubMed