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Conjugated Linoleic Acid (CLA) Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • GI discomfort (loose stools, bloating) in some users
  • May increase inflammatory markers (CRP) in some studies
  • Possible insulin resistance effect (t10,c12 isomer) — monitor if diabetic
  • Fatty liver concerns at very high doses in some animal studies

Drug & Supplement Interactions

  • Diabetes medications — t10,c12 isomer may affect insulin sensitivity
  • Anticoagulants — CLA may have mild platelet effects

Maximum Dose

Do not exceed: 6.4 g/day has been used safely in trials; higher doses offer no additional benefit

Full Conjugated Linoleic Acid (CLA) Guide

References

  1. (). Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. American Journal of Clinical Nutrition. DOI
  2. (). Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. American Journal of Clinical Nutrition. DOI