Evidence Level
DHEA supplementation has been studied across various populations and contexts, yielding mixed results. Villareal & Holloszy (2004) demonstrated that 50mg of DHEA daily for six months significantly reduced abdominal visceral fat by 7.4% in men and improved insulin sensitivity in elderly adults. Similarly, Jankowski et al. (2006) found that 50mg of DHEA daily for two years improved hip bone mineral density in older adults. However, Nair et al. (2006) reported no significant effects of 75mg DHEA daily for two years on body composition, physical performance, insulin sensitivity, or quality of life in elderly men.
Recent systematic reviews and meta-analyses provide additional insights. Qin et al. (2020) found that DHEA supplementation significantly reduced high-density lipoprotein cholesterol (HDL-C) levels (-3.1 mg/dL, p<0.05), while having no significant effect on total cholesterol, LDL-C, or triglycerides. Wang et al. (2020) reported that DHEA supplementation significantly reduced fasting plasma glucose (-2.185 mg/dl), but did not affect insulin levels or HOMA-IR index. Additionally, Zhu et al. (2023) conducted a systematic review and network meta-analysis of 16 RCTs (n=2323) and found that DHEA improved pregnancy outcomes in patients with poor ovarian response undergoing IVF-ET.
These findings suggest that DHEA supplementation may offer benefits in specific contexts, such as improving bone density or reducing fasting plasma glucose, but its effects on other outcomes remain inconsistent. The key takeaway is that DHEA should be considered a targeted intervention based on individual needs and blood testing rather than a universal supplement for anti-aging purposes.