Safety Profile
Overall safety rating: Generally Safe
DIM (Diindolylmethane) Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Mild GI discomfort (nausea, gas)
- Darkened urine (harmless)
- Headache at higher doses
- May alter menstrual cycle timing initially
Drug & Supplement Interactions
- May alter estrogen-sensitive medication efficacy (tamoxifen, aromatase inhibitors)
- May affect CYP1A2 enzyme activity — caution with caffeine and theophylline
- May interact with hormonal contraceptives
Maximum Dose
Do not exceed: 300mg daily (higher doses not well-studied in humans)
References
- Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF (2004). Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutrition and Cancer. DOI PubMed
- Del Priore G, Gudipudi DK, Montemarano N, Restivo AM, Malanowska-Stega J, Arslan AA (2010). Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecologic Oncology. DOI PubMed